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10212-25-6

10212-25-6 structure

10212-25-6 structure

Name: Cyclocytidine Hydrochloride
Chemical Name: ancitabine hydrochloride
CAS Number: 10212-25-6
Molecular Formula: C₉H₁₂ClN₃O₄
Molecular Weight: 261.662
Catalog: API Antineoplastic agents Antimetabolite antineoplastic
Create Date: 2018-05-27 08:00:00
Modify Date: 2026-07-03 19:24:37
Ancitabine (hydrochloride) is an important antileukemia drugs.

Name	ancitabine hydrochloride
Synonyms	Cyclo-Cr·HCl O2-2'-CYCLOCYTIDINE HYDROCHLORIDE 2,2’-anhydrocytabinehydrochloride 2,2'-ANHYDRO-(1-BETA-D-ABINOFURANOSYL)CYTOSINE HYDROCHLORIDE (2R,3R,3aS,9aR)-3-Hydroxy-2-(hydroxymethyl)-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-6-iminiumchlorid 2,2’-anhydro-1-beta-d-abinofuranosylcytosinhydrochloride MFCD00012636 {6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidine-2-methanol,} 2,3, 3a,9a-tetrahydro-3-hydroxy-6-imino-, {[2R-(2.alpha.,3.beta.,3a.beta.,9a.beta.)]-} Cytabine Impurity 21 CYCLOCYTIDINE HCL 2,2'-Anhydro-1-beta-D-abinofuranosylcytosine CYCLOCYTIDINE HCL(P) 3’:4,5)oxazolo(3,2-a)-pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-h-furo(2 2,2'-ANHYDROCYTIDINE HYDROCHLORIDE Ancitabine hydrochloride, O2,2μ-Cyclocytidine Cyclocytidine hydrochloride,2,2′-Anhydro-(1-β-D-abinofuranosyl)cytosine hydrochloride, 2,2′-Anhydro-1-β-D-abinofuranosylcytosine hydrochloride, Ancitabine, O2,2′-Cyclocytidine o-2,2’-cyclocytidinemonohydrochloride 2,2'-O-Cyclocytidine Hydrochloride NSC 145668 HCl 1-beta-d-abinofuranosyl-2,2’-anhydro-cytosinhydrochloride 2,2'-Anhydro-1-beta-D-abinofuranosylcytosine hydrochloride //BP Cyclocytidine hydrochloride / 2,2'-Anhydro-1-β-D-abinofuranosylcytosine hydrochloride 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, hydrochloride (1:1), (2R,3R,3aS,9) hydroxy-6-imino-,monohydrochloride,stereoisomer 2,2'-Anhydro-C.Hcl 2,2'-Anhydro-(1-beta-D-abinofuranosyl)cytosine Hydrochloride Ancitabine Hydrochloride (2R,3R,3aS,9aR)-2-(Hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-3-ol hydrochloride (1:1) CYCLOCYTIDINE HYDROCHLORIDE 2,2'-Anhydro-(1-β-D-arabinofuranosyl)cytosine Hydrochloride ANCITABINE HYDROCHLORIDE Ancitabine (Cyclocytidine) HCl 2,2'-O-Cyclocytidine Hydrochloride > (2R,3R,3aS,9aR)-3-Hydroxy-2-(hydroxymethyl)-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-6-iminium chloride 2,2-Anhydro-(1-B-D-abinofuranosyl)Cytosine Hydrochloride 2,2'-Anhydrocytidine HCl 2,2'-Anhydro-1-β-D-arabinofuranosylcytosine hydrochloride 2,2'-Anhydroacytidine hydrochloride 2,2'-Anhydro-1-beta Hydrochloric cyclocylidine ANHYDRO-1-B-D-ABINOFURANOSYL*CYTOSINE HCL OCTD hydrochloride (2R,3R,3aS,9-2,3,3a,9a-Tetrahydro-3-hydroxy-6-imino-6H-furo(2',3'4,5)oxazolo(3,2-a)pyrimidine-2-methanol EINECS 233-515-6 Cyclo-C, Cyclocytidine, 2,2μ-Anhydro-(1-β-D-abinofuranosyl)cytosine hydrochloride Cyclocytidine HC1 cyclo-cmphydrochloride Ancitabine (Cyclocytidine) hydrochloride Ancitabine, O2,2μ-Cyclocytidine, 2,2μ-Anhydro-1-β-D-abinofuranosylcytosine hydrochloride, 2,2μ-Anhydro-(1-β-D-abinofuranosyl)cytosine hydrochloride CYCLOCYTIDINE HCL(RG) cyclocytidine hydrochlorine 2,2’-Cyclocytidine hydrochloride, Ancytabine (-)-Cyclocytidine hydrochloride nsc-145668 ANCITABINE HCL CyclocytidiniHydrochlorinum 2,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride Cyclo-C Ancitabine Hydrochloride Cytidine reference substance Anhydro-Cr.HCl 2,2’-o-cyclocytidinehydrochloride 2,2’-anhydroabinosylcytosinehydrochloride 2,2μ-Anhydro-(1-β-D-abinofuranosyl)cytosine hydrochloride Ancitabine (hydrochloride) 6H-Furo(2',3':4,5)oxazolo(3,2-a)-pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy- 6-imino-, monohydrochloride, stereoisomer (2R,3R,3aS,9-2-(Hydroxymethyl)-6-imino-3,3a,6,9a-tetrahydro-2H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-ol hydrochloride Ancitabine hydrochloride,2,2′-Anhydro-(1-β-D-abinofuranosyl)cytosine hydrochloride, Cyclo-C, Cyclocytidine Cyclocytidini HydrochloriduM 2,2’-cyclocytidinehydrochloride 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, (2R,3R,3aS,9aR)-, hydrochloride (1:1)

Description	Ancitabine (hydrochloride) is an important antileukemia drugs.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Alkaloid Research Areas >> Cancer
References	[1]. Z Rao, et al. Study on the Synthesis of Cytarabine Hydrochloride and its Intermediate Ancitabine Hydrochloride. Fine Chemical Intermediates, 2013

Density	2.01 g/cm3
Boiling Point	442ºC at 760 mmHg
Melting Point	269-270ºC
Molecular Formula	C₉H₁₂ClN₃O₄
Molecular Weight	261.662
Flash Point	221.1ºC
Exact Mass	261.051636
PSA	100.59000
Index of Refraction	-21 ° (C=2， H2O)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV2615000

CAS REGISTRY NUMBER :: 10212-25-6

LAST UPDATED :: 199512

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C9-H11-N3-O4.Cl-H

MOLECULAR WEIGHT :: 261.69

WISWESSER LINE NOTATION :: T B555 AN CO GO IN JHTT&J D1Q EQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2528 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 344 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1045 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 560 mg/kg/7D-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1120 mg/kg/7D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 800 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 8250 mg/kg

SEX/DURATION :: male 2 year(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 60 mg/kg

SEX/DURATION :: female 8-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 60 mg/kg

SEX/DURATION :: female 8-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 125 mg/kg

SEX/DURATION :: female 8-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - body wall

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 20,2286,1972

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	LV2615000

Precursor 0
DownStream 3
3083-77-0 34079-68-0 147-94-4

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