578-74-5

578-74-5 structure

Name: Cosmosiin
Chemical Name: apigenin 7-O-β-D-glucoside
CAS Number: 578-74-5
Molecular Formula: C₂₁H₂₀O₁₀
Molecular Weight: 432.378
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-08-26 14:24:12
Modify Date: 2025-08-25 10:51:08
Apigenin-7-glucoside exhibits significant anti-proliferative and antioxidant activity, scavengers of ROS.In vitro: exhibits significant anti-proliferative activity against B16F10 melanoma cells after 24 and 48 h of incubation. Apigenin-7-glucoside provoks an increase of subG0/G1, S and G2/M phase cell proportion with a significant decrease of cell proportion in G0/G1 phases. Apigenin-7-glucoside enhances melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. [1] Api7G specifically induced the differentiation of CD34+ cells towards the erythroid lineage and inhibited the myeloid differentiation. [2] APIG had strong antioxidant activity against reactive oxygen species (ROS) in vitro in a concentration-dependent manner.

Name	apigenin 7-O-β-D-glucoside
Synonyms	Apigenin-7-O-Beta-D-glucopyranoside 4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)- Apigenin 7-β-glucoside Cosmosiin MFCD00016787 Cosmosioside Apigenin 7-glucoside Apigenin-7-O-β-D-glucopyranoside Cosmosiin (8CI) Apigenin 7-β-D-glucoside Cosmiin Cosmosin Thalictiin apigenin 7-O-beta-D-glucoside Apigenin-7-O-glucoside Apigetrin COSMETIN Cosemetin EINECS 209-430-5 7-D-Glycosylapigenin 5-Hydroxy-2-(4-hydroxyphényl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-4H-chromén-4-one 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl b-D-glucopyranoside Apigenin 7-O-β-D-glucopyranoside 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-β-D-glucopyranoside 5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-on 7-(b-D-Glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Cossmetin 5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4H-chromen-4-one Apigenin-7-d-glucoside Apigenin 7-O-β-glucoside Apigenin 7-β-D-glucopyranoside 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranoside Apigetrin,Cosmosiin Apigenin 7-O-glucoside 4H-1-Benzopyran-4-one, 7- (β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)- Apigenin-7-glucoside Apigenin-7-O-β-glucopyranoside apigenin 7-O-β-D-glucoside

Description	Apigenin-7-glucoside exhibits significant anti-proliferative and antioxidant activity, scavengers of ROS.In vitro: exhibits significant anti-proliferative activity against B16F10 melanoma cells after 24 and 48 h of incubation. Apigenin-7-glucoside provoks an increase of subG0/G1, S and G2/M phase cell proportion with a significant decrease of cell proportion in G0/G1 phases. Apigenin-7-glucoside enhances melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. [1] Api7G specifically induced the differentiation of CD34+ cells towards the erythroid lineage and inhibited the myeloid differentiation. [2] APIG had strong antioxidant activity against reactive oxygen species (ROS) in vitro in a concentration-dependent manner.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Flavonoids Research Areas >> Others
References	[1]. Nasr Bouzaiene N et al. Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. Life Sci. 2016 Jan 1;144:80-5. [2]. Samet I et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. Differentiation. 2015 Jun;89(5):146-55.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Precursor 0
DownStream 3
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