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59227-89-3 1003-51-6

59227-89-3

59227-89-3 structure
59227-89-3 structure
  • Name: Laurocapram
  • Chemical Name: Laurocapram
  • CAS Number: 59227-89-3
  • Molecular Formula: C18H35NO
  • Molecular Weight: 281.477
  • Catalog: Research Areas Others
  • Create Date: 2018-04-06 08:00:00
  • Modify Date: 2024-01-01 22:48:07
  • Laurocapram is a absorption enhancer and has been one of the most effective for substances of both lipophilic and hydrophilic nature[1].
Name Laurocapram
Synonyms 1-dodecyl-hexahydro-azepin-2-one
MFCD00190580
2H-Azepin-2-one, 1-dodecylhexahydro-
tranzone
acecloguanosine
EINECS 261-668-9
1-Dodecylazepan-2-one
Lauocapram
1 dodecylperhydroazepin 2 one
AZONE
N-Dodecyl-e-caprolactam
azon
1-Dodecyl-2-azepanone
1-dodecylhexahydro-2H-azepin-2-one
usafnd-72
Laurocapram
1-N-dodecylazacycloheptan-2-one
Description Laurocapram is a absorption enhancer and has been one of the most effective for substances of both lipophilic and hydrophilic nature[1].
Related Catalog
References

[1]. López-Cervantes M, et al. Chemical enhancers for the absorption of substances through the skin: Laurocapram and its derivatives. Drug Dev Ind Pharm. 2006 Mar;32(3):267-86.
Density 0.9±0.1 g/cm3
Boiling Point 404.9±14.0 °C at 760 mmHg
Melting Point -7ºC
Molecular Formula C18H35NO
Molecular Weight 281.477
Flash Point 165.2±10.7 °C
Exact Mass 281.271851
PSA 20.31000
LogP 6.57
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.466
Material Safety Data Sheet
Section1. Identification of the substance
Product Name: Laurocapram
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:Laurocapram
CAS number:59227-89-3
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C18H35NO
Molecular weight:281.5
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CM3995000
CHEMICAL NAME :
2H-Azepin-2-one, hexahydro-N-lauryl-
CAS REGISTRY NUMBER :
59227-89-3
BEILSTEIN REFERENCE NO. :
0167211
LAST UPDATED :
199806
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C18-H35-N-O
MOLECULAR WEIGHT :
281.54
WISWESSER LINE NOTATION :
T7NVTJ A12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 118,474,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983
Hazard Codes Xi
HS Code 2933790090
105-60-2 structure

105-60-2
143-15-7 structure

143-15-7

~99%

59227-89-3 structure

59227-89-3
Literature: KOEI Chemical Co., Ltd. Patent: US4812566 A1, 1989 ;
143-15-7 structure

143-15-7

~%

59227-89-3 structure

59227-89-3
Literature: US4422970 A1, ;
112-52-7 structure

112-52-7

~93%

59227-89-3 structure

59227-89-3
Literature: KOEI Chemical Co., Ltd. Patent: US4812566 A1, 1989 ;
105-60-2 structure

105-60-2
1634-04-4 structure

1634-04-4
143-15-7 structure

143-15-7

~%

59227-89-3 structure

59227-89-3
Literature: US5986092 A1, ;
112-53-8 structure

112-53-8

~%

59227-89-3 structure

59227-89-3
Literature: JAOCS, Journal of the American Oil Chemists' Society, , vol. 73, # 7 p. 847 - 850
105-60-2 structure

105-60-2

~%

59227-89-3 structure

59227-89-3
Literature: Journal of Organic Chemistry, , vol. 18, p. 1087,1088
HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

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