CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
GG3200000
-
CAS REGISTRY NUMBER :
-
10026-24-1
-
LAST UPDATED :
-
199712
-
DATA ITEMS CITED :
-
11
-
MOLECULAR FORMULA :
-
Co-O4-S.7H2-O
-
MOLECULAR WEIGHT :
-
281.13
-
WISWESSER LINE NOTATION :
-
.CO..S-O4 &QH 7
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
582 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
320 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
16200 ug/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
91 mg/m3/6H/16D-I
-
TOXIC EFFECTS :
-
Sense Organs and Special Senses (Eye) - chromodacryorrhea Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Endocrine - changes in thymus weight
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
18 mg/m3/6H/13W-I
-
TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - changes in lung weight Kidney, Ureter, Bladder - changes in bladder weight Blood - pigmented or nucleated red blood cells
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
30 mg/m3/6H/13W-I
-
TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - changes in lung weight Endocrine - effect on menstrual cycle Related to Chronic Data - changes in testicular weight
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
DOSE :
-
30 mg/m3/6H
-
SEX/DURATION :
-
male 13 week(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
MUTATION DATA
-
TYPE OF TEST :
-
Micronucleus test
-
TEST SYSTEM :
-
Rodent - hamster Embryo
-
DOSE/DURATION :
-
1 mg/L
-
REFERENCE :
-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 392,61,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2377 No. of Facilities: 126 (estimated) No. of Industries: 5 No. of Occupations: 5 No. of Employees: 3264 (estimated) No. of Female Employees: 1853 (estimated)
|