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12125-02-9 89485-85-8
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12125-02-9

12125-02-9 structure
12125-02-9 structure
  • Name: Ammonium Chloride
  • Chemical Name: ammonium chloride
  • CAS Number: 12125-02-9
  • Molecular Formula: ClH4N
  • Molecular Weight: 53.49150
  • Catalog: API Respiratory medication Peony
  • Create Date: 2018-02-03 08:00:00
  • Modify Date: 2024-01-02 16:08:15
  • Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor[1][2].
Name ammonium chloride
Synonyms Ammonium chloride
ammonia chloride
amine hydrochloride
Ammonium Chlorid
threo-amine hydrochloride
EINECS 235-186-4
ammonium cloride
MFCD00011420
Description Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor[1][2].
Related Catalog
In Vitro Ammonium chloride (NH4Cl), a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells[2].
In Vivo Ammonium chloride (0.28 M in drinking water) promotes the survival of myocardial cells in vivo by decreasing contractile dysfunction, cardiac hypertrophy, inflammation, apoptosis and autophagy[1]. Animal Model: 8-9-week-old C57B/L6 mice[1] Dosage: 0.28 M in drinking water (5 mg/kg doxorubicin once a week for 2 weeks) Administration: 0.28 M in drinking water (5 mg/kg doxorubicin once a week for 2 weeks) Result: Effectively improved doxorubicin (DOX)-induced cardiomyocyte apoptosis and cardiac dysfunction in mice.
References

[1]. Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100.

[2]. Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219(4587):987-988.

Density 1.52
Boiling Point 100 °C750 mm Hg
Melting Point 340 °C (subl.)(lit.)
Molecular Formula ClH4N
Molecular Weight 53.49150
Exact Mass 53.00320
LogP 1.17820
Vapour density 1.9 (vs air)
Vapour Pressure 1 mm Hg ( 160.4 °C)
Index of Refraction 1.642
Stability Stable. Incompatible with strong acids, strong bases.
Water Solubility soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BP4550000
CHEMICAL NAME :
Ammonium chloride
CAS REGISTRY NUMBER :
12125-02-9
LAST UPDATED :
199806
DATA ITEMS CITED :
38
MOLECULAR FORMULA :
Cl-H4-N
MOLECULAR WEIGHT :
53.50
WISWESSER LINE NOTATION :
Z& G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Cardiac - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
485 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
358 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
78 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
72 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
51660 mg/kg/10W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in calcium

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** ACGIH TLV-STEL 20 mg/m3, fume DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3, fume DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,12,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 10 mg/m3 (fume) JAN 1993 OEL-AUSTRALIA:TWA 10 mg/m3;STEL 20 mg/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 10 mg/m3;STEL 20 mg/m3 (fume) JAN 1993 OEL-DENMARK:TWA 10 mg/m3 (fume) JAN 1993 OEL-FRANCE:TWA 10 mg/m3 (fume) JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 (fume) JAN 1993 OEL-RUSSIA:STEL 10 mg/m3 (fume) JAN 1993 OEL-SWITZERLAND:TWA 6 mg/m3 (fume) JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 (fume) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO AMMONIUM CHLORIDE-air:10H TWA 10 mg/m3;STEL 20 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 05270 No. of Facilities: 29596 (estimated) No. of Industries: 223 No. of Occupations: 97 No. of Employees: 259567 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 05270 No. of Facilities: 24833 (estimated) No. of Industries: 180 No. of Occupations: 131 No. of Employees: 415676 (estimated) No. of Female Employees: 139037 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36
Safety Phrases S22-S36-S26
RIDADR UN 9085
WGK Germany 1
RTECS BP4550000
HS Code 2827101000
6141-81-7 structure

6141-81-7

~0%

94317-64-3 structure

94317-64-3
12125-02-9 structure

12125-02-9
Literature: AGRA GROUP, A.S.; KYSILKA, Vladimir; KOPENEC, Jiri; KREPELKA, Jiri Patent: WO2010/45895 A2, 2010 ; Location in patent: Page/Page column 11 ;
1467-16-9 structure

1467-16-9

~%

288-32-4 structure

288-32-4
12125-02-9 structure

12125-02-9
Literature: EP1731510 A1, ; Page/Page column 5 ;
79-37-8 structure

79-37-8
172733-07-2 structure

172733-07-2

~%

12125-02-9 structure

12125-02-9

172733-08-3 structure

172733-08-3
Literature: EP1058547 B1, ; Page/Page column 5 ;
7647-01-0 structure

7647-01-0
7664-41-7 structure

7664-41-7

~%

12125-02-9 structure

12125-02-9
Literature: WO2008/94664 A1, ; Page/Page column 25 ;
6569-51-3 structure

6569-51-3

~%

10294-34-5 structure

10294-34-5
12125-02-9 structure

12125-02-9
Literature: Angewandte Chemie - International Edition, , vol. 51, # 47 p. 11731 - 11735 Angew. Chem., , vol. 124, # 47 p. 11901 - 11905,5
318-98-9 structure

318-98-9

~%

124-38-9 structure

124-38-9
12125-02-9 structure

12125-02-9
Literature: Electrochimica Acta, , vol. 56, # 1 p. 215 - 221
HS Code 2827101000

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