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14698-29-4

14698-29-4 structure

14698-29-4 structure

Name: oxolinic acid
Chemical Name: oxolinic acid
CAS Number: 14698-29-4
Molecular Formula: C₁₃H₁₁NO₅
Molecular Weight: 261.230
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-06-28 18:52:23
Modify Date: 2026-07-03 11:49:40
Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.

Name	oxolinic acid
Synonyms	OXOLINIC ACID STANDD SOLUTION prodoxal uroxol OXOLINIC ACID IMPURITY emyrenil 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-cboxylic acid oxolinic acid wp 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid stner amurin ossian Oxolinic Acid 1-ethyl-6,7-methylenedioxo-4-quinoline-3-cboxlicacid 5-ETHYL-8-OXO-5,8-DIHYDRO-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CBOXYLIC ACID OXOLINIC ACID, QUINOLONE ANTIBIOTIC pietil oxolinic Oxolinate uro-alv Oxolinic acid 5-g)quinoline-7-cboxylicacid,5-ethyl-5,8-dihydro-8-oxo-3-dioxolo(4 5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-cboxylic acid utibid ultibid 1-ethyl-6,7-methylenedioxy-4-quinolone-3-cboxylicacid EINECS 238-750-8 1,3-Dioxolo4,5-gquinoline-7-cboxylic acid, 5-ethyl-5,8-dihydro-8-oxo 5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid nsc-110364 Oxlinic Acid Dioxacin(TM) Oxolinic Acid Standd MFCD00056775 Purity Oxolinic Acid 5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid Oxolinic acid CAS NO.: 14-4 CAS NO.14-4 5-Ethyl-5,8-dihydro-8-oxo 5-Ethyl-5,8-dihydro-8-oxo-1,3-dioxoloquinole-7-cboxylicacid nidantin 5-ethyl-8-keto-[1,3]dioxolo[4,5-g]quinoline-7-cboxylic acid 1-Ethyl-6,7-methylenedioxo-4-quinoline-3-cboxylic acid 5-ethyl-5,8-dihydro-8-oxo [1,3]-dioxolo [4,5-g] quinoline-7-boxylic acid Oxolinic acid@100 μg/mL in Acetonirtile oxolinic acid:5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo(4,5-g)QUINOLINE-7-cboxylic acid Oxilinic acid Oxolinic acid solution Oxolinic acid Solution, 1000ppm w4565 urotrate Oxolinic acid,5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-cboxylic acid 5-Ethyl-5,8-dihydro-8-oxo-1,3-Dioxolo[4,5-γ],quinoline-7-cboxylic Acid 5,8-DIHYDRO-5-ETHYL-8-OXO-1,3-DIOXOLO[4,5-G]QUINOLINE-7-CBOXYLIC ACID 5-g]quinoline-7-cboxylicacid,5-ethyl-5,8-dihydro-8-oxo-3-dioxolo[4 uritrate 5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid dioxacin OXOLINIC ACID F&D VERSION OF O0877 5-Ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 2,3-dihydrofuran-5-cboxylic acid s-0208 oxoboi 5-ethyl-5,8-dihydro-8-oxo[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 1-ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecboxylicacid prodoxol

Description	Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Infection

Density	1.5±0.1 g/cm3
Boiling Point	473.2±45.0 °C at 760 mmHg
Melting Point	314-316°C (dec.)
Molecular Formula	C₁₃H₁₁NO₅
Molecular Weight	261.230
Flash Point	240.0±28.7 °C
Exact Mass	261.063721
PSA	77.76000
LogP	1.43
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.638
Storage condition	2-8°C
Stability	Stable. Combustible.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JI5075000

CHEMICAL NAME :: 1,3-Dioxolo(4,5-g)quinoline-7-carboxylic acid, 5-ethyl-5,8-dihydro-8-oxo-

CAS REGISTRY NUMBER :: 14698-29-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C13-H11-N-O5

MOLECULAR WEIGHT :: 261.25

WISWESSER LINE NOTATION :: T C566 DO FO JN MV EHJ J2 LVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1890 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 177 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg/30D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 43800 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - testicular tumors

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 243,213,1990

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	JI5075000
HS Code	2934999090

Precursor 9
16172-03-5 50332-64-4 66176-21-4 57385-14-5
60792-24-7 32953-32-5 32953-14-3 32953-23-4
34841-20-8
DownStream 3
79721-05-4 57147-33-8 59587-08-5

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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