68247-85-8
68247-85-8 structure
- Name: N1-[3-[(1-Phenylethyl)amino]propyl]bleomycinamide
- Chemical Name: peplomycin
- CAS Number: 68247-85-8
- Molecular Formula: C61H88N18O21S2
- Molecular Weight: 1473.589
- Catalog: API Antineoplastic agents Antibiotic antineoplastic agents
- Create Date: 2018-09-22 08:35:21
- Modify Date: 2024-01-05 14:32:12
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Peplomycin (Bleomycin PEP; Pepleomycin) is an antibiotic analogue of Bleomycin (HY-108345), with high antitumor effect and less pulmonary toxicity. Peplomycin induce apoptosis in oral squamous carcinoma cell line SSCKN cells and pulmonary fibrosis in rats[1][2][3][4].
| Name | peplomycin |
|---|---|
| Synonyms |
PLM
N1-[3-[[(S)-a-Methylbenzyl]amino]propyl]bleomycinamide NK-631{PEP Peplocin Bleomycin PEP Pepleocine Pepreomycin (2R,3S,4S,5R,6R)-2-{[(2R,3S,4S,5S,6S)-2-[2-{[(6-Amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methyl-4-pyrimidinyl)carbonyl]amino}-3-{[3-hydroxy-5-({3-hydroxy-1-oxo-1-[(2-{4-[(3-{[(1S)-1-phenylethyl]amino}propyl)carbamoyl]-2,4'-bi-1,3-thiazol-2'-yl}ethyl)amino]-2-butanyl}amino)-4-methyl-5-oxo-2-pentanyl]amino}-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-3,5-dihydroxy-6 Pepleomycin PEP-Bleomycin 3((S)-1'-Phenylethylamino)-propylaminbleomycin N1-[3-[(1-Phenylethyl)amino]propyl]bleomycinamide |
| Description | Peplomycin (Bleomycin PEP; Pepleomycin) is an antibiotic analogue of Bleomycin (HY-108345), with high antitumor effect and less pulmonary toxicity. Peplomycin induce apoptosis in oral squamous carcinoma cell line SSCKN cells and pulmonary fibrosis in rats[1][2][3][4]. |
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| Related Catalog | |
| In Vitro | Peplomycin (0-100 μM; 30 h) inhibits human oral squamous carcinoma cell line SSCKN and SCCTF cells in a dose-dependent manner[3]. Peplomycin (1 μM and 10 μM; 30 h) results nuclear fragmentation and condensation of chromatin in cells dose-dependently and induces apoptosis[3]. Peplomycin (5 mg/mL; 7 d) induces pulmonary fibrosis separated from saline-injected rats (N-Fib) by differentiating fibroblasts to alpha-SMA-positive MF[4]. Cell Viability Assay[3] Cell Line: SSCKN and SCCTF cells Concentration: 0, 1, 5, 10, 50, and 100 μM Incubation Time: 30 hours Result: Decreased SSCKN and SCCTF cells viability dose-dependently up to 50 μM, and resulted the viability of 38% and 30% that of the control group, respectively. |
| In Vivo | Peplomycin (5 mg/kg; once daily) induces rat pulmonary fibroblasts to myofibroblasts (MF), while the peripheries of lungs adjacent to the pleura reveals advanced fibrosis with a small number of alpha-smooth muscle actin (alpha-SMA)-positive MF, which ultrastructurally possessed abundant microfilaments and cellular organelles[4]. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C61H88N18O21S2 |
| Molecular Weight | 1473.589 |
| Exact Mass | 1472.581299 |
| PSA | 695.58000 |
| LogP | 0.00 |
| Index of Refraction | 1.689 |
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