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80125-14-0

80125-14-0 structure
80125-14-0 structure
  • Name: Remoxipride
  • Chemical Name: 3-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxybenzamide
  • CAS Number: 80125-14-0
  • Molecular Formula: C16H23BrN2O3
  • Molecular Weight: 371.26900
  • Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
  • Create Date: 2018-03-07 08:00:00
  • Modify Date: 2024-01-02 19:57:23
  • (S)-Remoxipride ((-)-Remoxipride) is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM. (S)-Remoxipride can be used for the research of psychotic disorder[1].

Name 3-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxybenzamide
Synonyms Remoxipridum [INN-Latin]
(S)-remoxipride
(S)-3-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxybenzamide
Remoxiprida
(-)-N-ethyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl)pyrrolidine
remoxipiride
S(-)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,6-dimethoxy-benzamide
remoxipride
FLA-731
Romoxipride
Roxiam
Remoxipride [USAN:BAN:INN]
Remoxiprida [INN-Spanish]
Remoxipridum
MFCD00869705
Description (S)-Remoxipride ((-)-Remoxipride) is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM. (S)-Remoxipride can be used for the research of psychotic disorder[1].
Related Catalog
Target

D2 Receptor:1.57 μM (IC50)

D1 Receptor:>100 μM (IC50)

α1-Adrenoccptor:42 μM (IC50)

In Vitro (S)-Remoxipride (1-100 μM; 20 min) shows binding efficiency with IC50s of >100, 1.57 and 42 μM for dopamine D1, dopamine D2 and α1-Adrenoccptor, respectively[1].
In Vivo (S)-Remoxipride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs[1]. (S)-Remoxipride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [3H]spiperone from both striatal and extra-striatal areas[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 0.1-100 μM/kg Administration: Intraperitoneal injection; 0.1-100 μM/kg; 60 min prior to apomorphine Result: Blocked apomorphine-induced hyperactivity and dose-dependent blockaded apomorphine-induced behaviors in vivo. Animal Model: Male and female beagle dogs[1] Dosage: 0.25-5 μM/kg Administration: Oral gavage; 0.25-5 μM/kg; 60 min prior to apomorphine Result: Blocked apomorphine-induced vomiting in dogs.
Density 1.292
Boiling Point 439.9ºC at 760 mmHg
Molecular Formula C16H23BrN2O3
Molecular Weight 371.26900
Flash Point 219.8ºC
Exact Mass 370.08900
PSA 50.80000
LogP 3.00920
Index of Refraction 1.54

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV2368700
CHEMICAL NAME :
Benzamide, 3-bromo-2,6-dimethoxy-N-((1-ethyl-2-pyrrolidinyl)meth yl)-, (S)-
CAS REGISTRY NUMBER :
80125-14-0
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H23-Br-N2-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
720 mg/kg/17W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Blood - hemorrhage Blood - aplastic anemia
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 342,1244,1993
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36-S24/25
WGK Germany 3