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108-30-5

108-30-5 structure

Name: Succinic anhydride
Chemical Name: succinic anhydride
CAS Number: 108-30-5
Molecular Formula: C₄H₄O₃
Molecular Weight: 100.073
Catalog: Organic raw materials Carboxylic compounds and derivatives Halogenation, sulfonation, nitration or nitration of carboxylic anhydrides
Create Date: 2018-02-07 08:00:00
Modify Date: 2024-01-01 18:01:30
Succinic anhydride is a cyclic anhydride and an ADC linker extracted from patent WO2009064913A1. It can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide[1].

Name	succinic anhydride
Synonyms	SAN 3,4-dihydrofuran-2,5-dione succinylanhydride Dihydrofuran-2,5-dione dihydro-furan-2.5-dione succinic acid anhydride tetrahydrofuran-2,5-dione Oxolan-2,5-dione SAA Succinic Anhydride SUCCINYL OXIDE 2,5-Diketotetrahydrofuran dihydrothran-2,5-dione MFCD00005525 dihydro-2,5-furandione EINECS 203-570-0

Description	Succinic anhydride is a cyclic anhydride and an ADC linker extracted from patent WO2009064913A1. It can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Alkyl/ether
References	[1]. Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.

Density	1.4±0.1 g/cm3
Boiling Point	261.0±0.0 °C at 760 mmHg
Melting Point	118-120 °C(lit.)
Molecular Formula	C₄H₄O₃
Molecular Weight	100.073
Flash Point	122.1±15.9 °C
Exact Mass	100.016045
PSA	43.37000
LogP	-1.30
Vapour density	3.5 (vs air)
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.470
Storage condition	Store at 0-5°C
Stability	Stable. Incompatible with oxidising agents, strong acids, strong bases, alcohols, amines. Avoid exposure to water or moisture.
Water Solubility	<0.1 g/100 mL at 21 ºC (decomposes)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WN0875000

CHEMICAL NAME :: Succinic anhydride

CAS REGISTRY NUMBER :: 108-30-5

BEILSTEIN REFERENCE NO. :: 0108441

LAST UPDATED :: 199710

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C4-H4-O3

MOLECULAR WEIGHT :: 100.08

WISWESSER LINE NOTATION :: T5VOVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1510 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2618 mg/kg/20D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 mg/kg/16D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19500 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2600 mg/kg/65W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 79 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 100 ug/L

REFERENCE :: IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 19,642,1977 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,265,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,265,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4008 No. of Facilities: 263 (estimated) No. of Industries: 7 No. of Occupations: 5 No. of Employees: 3059 (estimated) No. of Female Employees: 1207 (estimated)

Symbol	GHS05, GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H314-H317-H334-H335
Precautionary Statements	P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37
Safety Phrases	S25
RIDADR	UN 3261 8 / PGII
WGK Germany	1
RTECS	WN0875000
HS Code	2932999099

Precursor 10
201230-82-2 75-56-9 108-31-6 75-21-8
110-15-6 543-20-4 111-40-0 57-57-8
110-16-7 106-97-8
DownStream 10
10484-48-7 1083-11-0 109591-76-6 109164-38-7
1083-55-2 107832-33-7 108032-13-9 4975-21-7
4146-43-4 35656-89-4

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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