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108-30-5

108-30-5 structure
108-30-5 structure
Name succinic anhydride
Synonyms SAN
3,4-dihydrofuran-2,5-dione
succinylanhydride
Dihydrofuran-2,5-dione
dihydro-furan-2.5-dione
succinic acid anhydride
tetrahydrofuran-2,5-dione
Oxolan-2,5-dione
SAA
Succinic Anhydride
SUCCINYL OXIDE
2,5-Diketotetrahydrofuran
dihydrothran-2,5-dione
MFCD00005525
dihydro-2,5-furandione
EINECS 203-570-0
Description Succinic anhydride is a cyclic anhydride and an ADC linker extracted from patent WO2009064913A1. It can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide[1].
Related Catalog
Target

Alkyl/ether

References

[1]. Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.
Density 1.4±0.1 g/cm3
Boiling Point 261.0±0.0 °C at 760 mmHg
Melting Point 118-120 °C(lit.)
Molecular Formula C4H4O3
Molecular Weight 100.073
Flash Point 122.1±15.9 °C
Exact Mass 100.016045
PSA 43.37000
LogP -1.30
Vapour density 3.5 (vs air)
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.470
Storage condition Store at 0-5°C
Stability Stable. Incompatible with oxidising agents, strong acids, strong bases, alcohols, amines. Avoid exposure to water or moisture.
Water Solubility <0.1 g/100 mL at 21 ºC (decomposes)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WN0875000
CHEMICAL NAME :
Succinic anhydride
CAS REGISTRY NUMBER :
108-30-5
BEILSTEIN REFERENCE NO. :
0108441
LAST UPDATED :
199710
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C4-H4-O3
MOLECULAR WEIGHT :
100.08
WISWESSER LINE NOTATION :
T5VOVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13 gm/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2618 mg/kg/20D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10500 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19500 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2600 mg/kg/65W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
79 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Embryo
DOSE/DURATION :
100 ug/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 19,642,1977 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,265,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,265,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4008 No. of Facilities: 263 (estimated) No. of Industries: 7 No. of Occupations: 5 No. of Employees: 3059 (estimated) No. of Female Employees: 1207 (estimated)
Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H314-H317-H334-H335
Precautionary Statements P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37
Safety Phrases S25
RIDADR UN 3261 8 / PGII
WGK Germany 1
RTECS WN0875000
HS Code 2932999099
HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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