756525-91-4

756525-91-4 structure

Name: Boc-NH-PEG4-CH2CH2COOH
Chemical Name: 3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
CAS Number: 756525-91-4
Molecular Formula: C₁₆H₃₁NO₈
Molecular Weight: 365.419
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-12-04 17:28:54
Modify Date: 2025-08-27 02:13:17
Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2].

Name	3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Synonyms	15-T-BUTYLOXYCARBONYLAMINO-4,7,10,13-TETRAOXA-PENTADECANOIC ACID 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid 3,8,11,14,17-Pentaoxa-5-azaeicosan-20-oic acid, 2,2-dimethyl-4-oxo- AmbotzPEG1920

Description	Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
References	[1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2018114798A1. [2]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport