20525-20-6
20525-20-6 structure
- Name: 4′-Bromoflavone
- Chemical Name: 2-(4-bromophenyl)chromen-4-one
- CAS Number: 20525-20-6
- Molecular Formula: C15H9BrO2
- Molecular Weight: 301.13
- Catalog: Research Areas Cancer
- Create Date: 2018-11-24 07:05:27
- Modify Date: 2024-01-14 10:20:44
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4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer[1].
| Name | 2-(4-bromophenyl)chromen-4-one |
|---|---|
| Synonyms |
4'-Bromo-flavone
4'-bromofalvone |
| Description | 4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 4′-Bromoflavone significantly induces quinone reductase (QR) activity in cultured murine hepatoma 1c1c7 cells (concentration to double activity: 10 nM) and effectively induces the α- and mu-isoforms of glutathione S-transferase in cultured H4IIE rat hepatoma cells with no observed toxicity[1]. 4′-Bromoflavone is a potent inhibitor of cytochrome P4501A1-mediated ethoxyresorufin-O-deethylase activity, with an IC50 of 0.86 μM. In HepG2 or MCF-7 cells, 4′-Bromoflavone significantly reduces the covalent binding of metabolically activated benzo[a]pyrene to cellular DNA[1]. |
| In Vivo | In short-term dietary studies, 4′-Bromoflavone is also shown to increase QR activity and glutathione levels in rat liver, mammary gland, colon, stomach, and lung in a dose-dependent manner. In studies conducted with female Sprague Dawley rats ,4′-Bromoflavone significantly increases QR activity (phase II enzyme)[1]. In DMBA-treated female Sprague Dawley rats. Dietary administration of 4′-Bromoflavone (2000 and 4000 mg/kg of diet, from 1 week before to 1 week after DMBA) significantly inhibits the incidence and multiplicity of mammary tumors and greatly increases tumor latency[1]. |
| References |
| Density | 1.54g/cm3 |
|---|---|
| Boiling Point | 406.6ºC at 760 mmHg |
| Melting Point | 174-176ºC |
| Molecular Formula | C15H9BrO2 |
| Molecular Weight | 301.13 |
| Flash Point | 199.7ºC |
| Exact Mass | 299.97900 |
| PSA | 30.21000 |
| LogP | 4.22250 |
| Vapour Pressure | 8.07E-07mmHg at 25°C |
| Index of Refraction | 1.656 |
| HS Code | 2914700090 |
|---|
| Precursor 9 | |
|---|---|
| DownStream 1 | |
| HS Code | 2914700090 |
|---|---|
| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |