DC Chemicals Limited
China
Product Name: ZINC77292789(Fmoc-Thr(galnac(Ac)3-alpha-D)-OH)
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: FMOC-THR(GALNAC(AC)3-ALPHA-D)-OH
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

116783-35-8

116783-35-8 structure

116783-35-8 structure

Name: Fmoc-Thr[GalNAc(Ac)3-α-D]-OH
Chemical Name: N-Fmoc-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-threonine
CAS Number: 116783-35-8
Molecular Formula: C₃₃H₃₈N₂O₁₃
Molecular Weight: 670.660
Catalog: Biochemical Amino acids and their derivatives Threonine derivative
Create Date: 2018-12-28 17:54:56
Modify Date: 2024-01-02 14:13:15
Fmoc-Thr[GalNAc(Ac)3-α-D]-OH i a building block in the development of cancer vaccine.

Name	N-Fmoc-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-threonine
Synonyms	FMOC-THR(GALNAC(AC)3-α-D)-OH α-D-Galactopyranoside, (1R,2S)-2-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate (2R,3R)-3-{[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid (non-preferred name) (2S,3R)-3-{[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid α-D-Galactopyranoside, (1R,2R)-2-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate Fmoc-Thr[GalNAc(Ac)3-α-D]-OH

Description	Fmoc-Thr[GalNAc(Ac)3-α-D]-OH i a building block in the development of cancer vaccine.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Inflammation/Immunology Peptides
In Vitro	The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome[1].
References	[1]. Ju T, et al. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 1;14(1):63-81.

Density	1.4±0.1 g/cm3
Boiling Point	857.1±65.0 °C at 760 mmHg
Melting Point	178-183 °C
Molecular Formula	C₃₃H₃₈N₂O₁₃
Molecular Weight	670.660
Flash Point	472.1±34.3 °C
Exact Mass	670.237366
PSA	202.09000
LogP	4.58
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.592
Storage condition	-15°C

RIDADR	NONH for all modes of transport

Precursor 9
136497-89-7 120173-56-0 67673-39-6 73724-48-8
120791-77-7 84278-00-2 100938-55-4 167939-15-3
1772-03-8
DownStream 0