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40126-30-5

40126-30-5 structure
40126-30-5 structure
  • Name: H-cis-Hyp-OMe hydrochloride
  • Chemical Name: H-Cis-Hyp-Ome Hcl
  • CAS Number: 40126-30-5
  • Molecular Formula: C6H12ClNO3
  • Molecular Weight: 181.617
  • Catalog: Biochemical Amino acids and their derivatives Proline derivatives
  • Create Date: 2019-01-01 14:18:59
  • Modify Date: 2024-01-02 11:08:18
  • H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
Name H-Cis-Hyp-Ome Hcl
Synonyms H-cis-Hyp-OMe.HCl
Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (1:1)
Trans-4-hydroxy-L-proline methyl ester hydrochloride
Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1)
L-Proline, 4-hydroxy-, methyl ester, (4S)-, hydrochloride (1:1)
L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1)
(2S,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate,hydrochloride
cis-4-Hydroxy-L-proline methyl ester hydrochloride
Description H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Boiling Point 282.3ºC at 760 mmHg
Molecular Formula C6H12ClNO3
Molecular Weight 181.617
Flash Point 124.5ºC
Exact Mass 181.050568
PSA 58.56000
LogP 0.01300
Storage condition 2-8°C
Material Safety Data Sheet
Section1. Identification of the substance
Product Name: Cis-4-hydroxy-L-proline methyl ester, HCl
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:Cis-4-hydroxy-L-proline methyl ester, HCl
CAS number:40126-30-5
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C6H11NO3.ClH
Molecular weight:181.6
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A
Hazard Codes Xi
Precursor  0

DownStream  1


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