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  • DC Chemicals Limited
  • China
  • Product Name: SphK-I2
  • Price: $400.0/100mg $750.0/250mg $1500.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

312636-16-1

312636-16-1 structure
312636-16-1 structure
  • Name: SKI II
  • Chemical Name: 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
  • CAS Number: 312636-16-1
  • Molecular Formula: C15H11ClN2OS
  • Molecular Weight: 302.779
  • Catalog: Biochemical Inhibitor G protein coupled receptor(GPCR & G Protein) S1P Receptor Inhibitor
  • Create Date: 2018-12-29 10:47:20
  • Modify Date: 2024-01-03 01:47:54
  • SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 μM for SK1 and 45 μM for SK2.IC50 value: 78/45 μM (SK1/2) [2]Target: SKin vitro: SKI II inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway. SKI II also reduces the expression of c-Myc and cyclin D1, the downstream target genes of the Wnt signaling pathway. SKI II inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway. SKI II promotes the degradation of β-catenin by enhancing Wnt5A. SKI II inhibits the proliferation of HepG2 cells by blocking the Wnt/β-catenin signaling pathway. [1]in vivo: SKI-II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. In the present study, SKI-II was administered 3-weekly i.p. to LDL-R-/- mice for 16 weeks at a dose previously demonstrated to reduce tumor growth in mice. Preliminary experiments revealed that a single administration of SKI-II produces a significant reduction of plasma S1P with the maximum (40%) observed 12 h after injection. [2]

Name 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
Synonyms 4-{[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]amino}phenol
Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol
Kinome_2076
Phenol (4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]
SKI II
SphK-I2,Sphingosine Kinase Inhibitor 2
UUL
Description SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 μM for SK1 and 45 μM for SK2.IC50 value: 78/45 μM (SK1/2) [2]Target: SKin vitro: SKI II inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway. SKI II also reduces the expression of c-Myc and cyclin D1, the downstream target genes of the Wnt signaling pathway. SKI II inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway. SKI II promotes the degradation of β-catenin by enhancing Wnt5A. SKI II inhibits the proliferation of HepG2 cells by blocking the Wnt/β-catenin signaling pathway. [1]in vivo: SKI-II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. In the present study, SKI-II was administered 3-weekly i.p. to LDL-R-/- mice for 16 weeks at a dose previously demonstrated to reduce tumor growth in mice. Preliminary experiments revealed that a single administration of SKI-II produces a significant reduction of plasma S1P with the maximum (40%) observed 12 h after injection. [2]
Related Catalog
References

[1]. Liu H, et al. SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/β-catenin signaling pathway. Life Sci. 2016 Apr 15;151:23-9.

[2]. Potì F, et al. SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet. Atherosclerosis. 2015 May;240(1):212-5.

[3]. Liu Y, et al. SKI-II reverses the chemoresistance of SGC7901/DDP gastric cancer cells. Oncol Lett. 2014 Jul;8(1):367-373.

Density 1.4±0.1 g/cm3
Boiling Point 507.1±60.0 °C at 760 mmHg
Molecular Formula C15H11ClN2OS
Molecular Weight 302.779
Flash Point 260.5±32.9 °C
Exact Mass 302.028076
PSA 73.39000
LogP 3.91
Appearance white solid
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.709
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport