267654-00-2

267654-00-2 structure

Name: BML-259
Chemical Name: 2-phenyl-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide
CAS Number: 267654-00-2
Molecular Formula: C₁₄H₁₆N₂OS
Molecular Weight: 260.35
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2016-02-02 11:58:11
Modify Date: 2024-01-05 11:38:01
BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].

Name	2-phenyl-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide
Synonyms	2-phenyl-N-[5-(propan-2-yl)-1,3-thiazol-2-yl]acetamide Benzeneacetamide, N-[5-(1-methylethyl)-2-thiazolyl]- N-(5-Isopropyl-1,3-thiazol-2-yl)-2-phenylacetamide

Description	BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease
In Vitro	BML-259 (10 μM) protects large population of cells against non-Aβ component of Alzheimer's disease amyloid (NAC)-evoked cell death[2].
References	[1]. Kaźmierczak A, et al. A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5). Neurochem Int. 2011;58(2):206-214.