BML-259

Modify Date: 2025-09-18 19:20:45

BML-259 structure	Common Name	BML-259
	CAS Number	267654-00-2	Molecular Weight	260.35
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₆N₂OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BML-259

BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].

Name	2-phenyl-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide
Synonym	More Synonyms

Description	BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease
In Vitro	BML-259 (10 μM) protects large population of cells against non-Aβ component of Alzheimer's disease amyloid (NAC)-evoked cell death[2].
References	[1]. Kaźmierczak A, et al. A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5). Neurochem Int. 2011;58(2):206-214.

Density	1.2±0.1 g/cm3
Molecular Formula	C₁₄H₁₆N₂OS
Molecular Weight	260.35
Exact Mass	260.098328
PSA	70.23000
LogP	3.88
Index of Refraction	1.618
InChIKey	IGRZXNLKVUEFDM-UHFFFAOYSA-N
SMILES	CC(C)c1cnc(NC(=O)Cc2ccccc2)s1

Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist

Name: Thermal Shift Assay. Domain: start/stop: N44-E168
Source: ChEMBL
Target: Bromodomain-containing protein 4
External Id: CHEMBL5060944

Name: Thermal Shift Assay. Domain start/stop: M626-G740
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL4650107

Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802

Name: Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infe...
Source: ChEMBL
Target: Cyclin-dependent kinase 9
External Id: CHEMBL4309975

Name: Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus ...
Source: ChEMBL
Target: CDK-activating kinase assembly factor MAT1
External Id: CHEMBL4309974

Name: Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected ...
Source: ChEMBL
Target: Cyclin-dependent kinase 5
External Id: CHEMBL4309973

Name: Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia col...
Source: ChEMBL
Target: Cyclin-A2
External Id: CHEMBL4309972

Name: Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus inf...
Source: ChEMBL
Target: Cyclin-dependent kinase 4
External Id: CHEMBL4309971

Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100

Total 44, Current Page 1 of 5

2-phenyl-N-[5-(propan-2-yl)-1,3-thiazol-2-yl]acetamide

N-(5-Isopropyl-1,3-thiazol-2-yl)-2-phenylacetamide

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

BML-259

Use of BML-259

Names

BML-259 Biological Activity

Chemical & Physical Properties

BML-259Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.