122520-85-8
122520-85-8 structure
- Name: AG 99
- Chemical Name: 2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
- CAS Number: 122520-85-8
- Molecular Formula: C10H8N2O3
- Molecular Weight: 204.182
- Catalog: Biochemical Amino acids and their derivatives Tyrosine derivatives
- Create Date: 2018-07-12 21:02:55
- Modify Date: 2026-07-11 08:31:46
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(E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) is a potent EGFR inhibitor[1].
| Name | 2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide |
|---|---|
| Synonyms |
TYRPHOSTIN A46
TYRPHOSTIN 46 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) (E)-2-Cyano-3-(3,4-dihydroxyphenyl)propenamide 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E) 3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE (E)-AG 99, 10 mM in DMSO TYRPHOSTIN AG 99 (E)-AG 99 (AG99) AG 99 //BP IN1036 (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENAMIDE TYRPHOSTIN B40 HMS3266G04 inhibit,Inhibitor,(E) AG 99,idermal owth factor rector,HER1,ErbB-1,EGFR,(E)AG 99,(E)-AG 99 (E)-Tyrphostin 46 (E)-2-Cyano-3-(3,4-Dihydroxyphenyl)Prop-2-Enamide (E)-Tyrphostin AG 99 ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE 3,4-dihydroxybenzalcyanoacetamide Tyrphostin A46 (E)-AG 99 (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide Tyrphostin AG 99 |
| Description | (E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) is a potent EGFR inhibitor[1]. |
|---|---|
| Related Catalog | |
| Target |
EGFR |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 544.4±50.0 °C at 760 mmHg |
| Melting Point | 231 °C |
| Molecular Formula | C10H8N2O3 |
| Molecular Weight | 204.182 |
| Flash Point | 283.0±30.1 °C |
| Exact Mass | 204.053497 |
| PSA | 107.34000 |
| LogP | 0.02 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.711 |
| Storage condition | Desiccate at +4°C |
|
~71%
122520-85-8 |
| Literature: Yissum Research Development Company of the Hebrew University of Jerusalem Patent: US5217999 A1, 1993 ; US 5217999 A |
|
~69%
122520-85-8 |
| Literature: Hussoin; FitzGerald; Wick Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 5 p. 416 - 418 |
|
~%
122520-85-8 |
| Literature: Rosenmund; Boehm Justus Liebigs Annalen der Chemie, 1924 , vol. 437, p. 143 |
|
~%
122520-85-8 |
| Literature: Piccinini Chem. Zentralbl., 1904 , vol. 75, # II p. 903 |
|
~%
122520-85-8 |
| Literature: Rosenmund; Boehm Justus Liebigs Annalen der Chemie, 1924 , vol. 437, p. 143 |
| Precursor 5 | |
|---|---|
| DownStream 0 | |