118409-57-7

118409-57-7 structure

Name: AG 18
Chemical Name: Tyrphostin 23
CAS Number: 118409-57-7
Molecular Formula: C₁₀H₆N₂O₂
Molecular Weight: 186.167
Catalog: Biochemical Amino acids and their derivatives Tyrosine derivatives
Create Date: 2018-04-10 08:00:00
Modify Date: 2024-01-02 08:39:28
Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.

Name	Tyrphostin 23
Synonyms	2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile (3,4-dihydroxybenzylidene)propanedinitrile MFCD00133899 (3,4-Dihydroxybenzylidene)malononitrile RG-50810 (3,4-Dihydroxybenzylidene)malononitrile Propanedinitrile, 2-[(3,4-dihydroxyphenyl)methylene]- AG 18 AG-18

Description	Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.
Related Catalog	Research Areas >> Cancer
Target	EGFR:35 μM (IC50, Cell Assay) EGFR:11 μM (Ki)
In Vitro	10 μM tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1μM ghrelin[2]. Tyrphostin 23 (T23) is a well-known inhibitor of protein tyrosine kinases and has been considered as potential anti-cancer drug. T23 is reported to acutely stimulate the glycolytic flux in primary cultured astrocytes. Tyrphostin 23 stimulates glycolytic flux in cultured astrocytes. Mitochondrial metabolism of brain astrocytes is accelerated by Tyrphostin 23 exposure[3].
References	[1]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. [2]. Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151(2):233-40. [3]. Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21.

Density	1.4±0.1 g/cm3
Boiling Point	421.1±45.0 °C at 760 mmHg
Melting Point	225ºC
Molecular Formula	C₁₀H₆N₂O₂
Molecular Weight	186.167
Flash Point	208.5±28.7 °C
Exact Mass	186.042923
PSA	88.04000
LogP	0.99
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.697
Storage condition	2-8°C
Water Solubility	Soluble in DMSO, ethanol, or DMF

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

6515-06-6

109-77-3

~0%

495411-89-7

118409-57-7

Literature: Wang, Bing; Zhang, Yong-Kang; Chen, Jian; Zhang, Wei; Song, Jiangao; Del Balzo, Ughetta; Brown, Lesley; Boddupalli, Sekhar; Bobzin, Steven; Gilat, Sylvain; Miller, Guy Patent: US2003/73712 A1, 2003 ;

109-77-3

139-85-5

~88%

118409-57-7

Literature: Riedel, Franziska; Spange, Stefan Journal of Physical Organic Chemistry, 2012 , vol. 25, # 12 p. 1261 - 1268

110-89-4

109-77-3

139-85-5

~87%

118409-57-7

Literature: Yissum Research Development Company of the Hebrew University of Jerusalem Patent: US5217999 A1, 1993 ; US 5217999 A

Precursor 4
6515-06-6 109-77-3 139-85-5 110-89-4
DownStream 1
122520-85-8

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