117857-93-9

117857-93-9 structure

Name: (2S)-ISOPROPYLPIPERAZINE
Chemical Name: (2S,1′S,2′S)-2-(Carboxycyclopropyl)glycine
CAS Number: 117857-93-9
Molecular Formula: C₆H₉NO₄
Molecular Weight: 159.14000
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2018-11-24 19:35:02
Modify Date: 2024-01-08 08:40:31
L-CCG-I is an extended isomer of conformationally restricted glutamate analog. L-CCG-I also is a potent agonist for mGluR2 with an EC50 value of 0.3 nM. L-CCG-I can be used for the research of mGluR family[1].

Name	(2S,1′S,2′S)-2-(Carboxycyclopropyl)glycine
Synonyms	(2s,1's,2's)-2-(carboxycyclopropyl)glycine MFCD00216830

Description	L-CCG-I is an extended isomer of conformationally restricted glutamate analog. L-CCG-I also is a potent agonist for mGluR2 with an EC50 value of 0.3 nM. L-CCG-I can be used for the research of mGluR family[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Metabolic Disease
Target	mGluR2:0.3 nM (EC50)
In Vitro	L-CCG-I 对 mGluR2 具有活性，EC50 值为 0.3 nM[1]。 L-CCG-I 有效刺激表达 mGluR1 的细胞中的磷脂酰肌醇水解[1]。 L-CCG-I 可抑制毛喉素刺激的腺苷 3':5'-环磷酸（环AMP）在 mGluR2 表达细胞中的积累[1]。 L-CCG-I 引起 mGluR4 毛喉素刺激的环 AMP 生成特征的抑制[1]。
References	[1]. Y Hayashi, et al. Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br J Pharmacol. 1992 Oct;107(2):539-43.

WGK Germany	3