118685-91-9

118685-91-9 structure

Name: sarcosine-methyl-d3
Chemical Name: sarcosine-methyl-d3
CAS Number: 118685-91-9
Molecular Formula: C₃H₄D₃NO₂
Molecular Weight: 92.11170
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GlyT
Create Date: 2016-02-20 08:04:29
Modify Date: 2024-01-05 17:55:34
Sarcosine-d3 (N-Methylglycine-d3) is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

Name	sarcosine-methyl-d3
Synonyms	n-Tridecyloxyessigsaeure-methylester MFCD01075434 N-trideuteriomethyl-glycine N-Methyl-d3-glycine

Description	Sarcosine-d3 (N-Methylglycine-d3) is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Signaling Pathways >> Neuronal Signaling >> GlyT
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [3]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7. [4]. Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18. [5]. Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62(2):392-7.

Density	1.13g/cm3
Boiling Point	195.1ºC at 760 mmHg
Melting Point	208ºC (dec.)(lit.)
Molecular Formula	C₃H₄D₃NO₂
Molecular Weight	92.11170
Flash Point	71.8ºC
Exact Mass	92.06650
PSA	49.33000
Vapour Pressure	0.184mmHg at 25°C
Index of Refraction	1.431

RIDADR	NONH for all modes of transport
WGK Germany	3

1080-44-0

118685-91-9

Literature: MacKenzie; Abeles Journal of Biological Chemistry, 1956 , vol. 222, p. 145,148

Precursor 1
1080-44-0
DownStream 0

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