929202-07-3

929202-07-3 structure

Name: (2S)-2-amino-4,4,4-trideuteriobutanoic acid
Chemical Name: (2S)-2-amino-4,4,4-trideuteriobutanoic acid
CAS Number: 929202-07-3
Molecular Formula: C₄H₆D₃NO₂
Molecular Weight: 106.13800
Catalog: Research Areas Metabolic Disease
Create Date: 2017-01-02 23:22:27
Modify Date: 2024-01-11 18:11:18
H-Abu-OH-d3 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

Name	(2S)-2-amino-4,4,4-trideuteriobutanoic acid
Synonyms	(2S)-2-Aminobutanoic Acid-d3 H-2-ABU-OH-d3 L-Butyrine-d3 LH-L-ABU-OH-d3 L-Aminobutyric Acid-d3 L-\|A-2-Aminobutyric Acid-d3 L-Ethylglycine-d3

Description	H-Abu-OH-d3 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yudkoff M, et al. On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio. Am J Clin Nutr. 1979 Feb;32(2):282-5.