13191-15-6

13191-15-6 structure

Name: Cytarabine triphosphate
Chemical Name: 4-Amino-1-[5-O-(hydroxy{[hydroxy(phosphonomethyl)phosphoryl]oxy}p hosphoryl)-β-D-arabinofuranosyl]-2(1H)-pyrimidinone
CAS Number: 13191-15-6
Molecular Formula: C₁₀H₁₈N₃O₁₃P₃
Molecular Weight: 481.18400
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2017-11-30 17:26:36
Modify Date: 2024-01-11 11:31:21
Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].

Name	4-Amino-1-[5-O-(hydroxy{[hydroxy(phosphonomethyl)phosphoryl]oxy}p hosphoryl)-β-D-arabinofuranosyl]-2(1H)-pyrimidinone

Description	Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
References	[1]. Anderson E, et, al. Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia. Exp Hematol. 2019 Jun;74:13-18.e3.

CHEMICAL NAME :: Cytosine, 1-beta-D-arabinofuranosyl-, 5'-(tetrahydrogen triphosphate)

REFERENCE :: BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 425,1,1976