Cytarabine triphosphate

Modify Date: 2025-08-22 16:14:01

Cytarabine triphosphate Structure
Cytarabine triphosphate structure
 Common Name Cytarabine triphosphate
CAS Number 13191-15-6 Molecular Weight 481.18400
Density 2.5g/cm3 Boiling Point 849.2ºC at 760mmHg
Molecular Formula C10H18N3O13P3 Melting Point N/A
MSDS N/A Flash Point 467.4ºC

 Use of Cytarabine triphosphate


Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].

 Names

Name 4-Amino-1-[5-O-(hydroxy{[hydroxy(phosphonomethyl)phosphoryl]oxy}p hosphoryl)-β-D-arabinofuranosyl]-2(1H)-pyrimidinone

 Cytarabine triphosphate Biological Activity

Description Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].
Related Catalog
References

[1]. Anderson E, et, al. Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia. Exp Hematol. 2019 Jun;74:13-18.e3.

 Chemical & Physical Properties

Density 2.5g/cm3
Boiling Point 849.2ºC at 760mmHg
Molecular Formula C10H18N3O13P3
Molecular Weight 481.18400
Flash Point 467.4ºC
Exact Mass 481.00500
PSA 291.61000
Index of Refraction 1.638

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA5590000
CHEMICAL NAME :
Cytosine, 1-beta-D-arabinofuranosyl-, 5'-(tetrahydrogen triphosphate)
CAS REGISTRY NUMBER :
13191-15-6
LAST UPDATED :
199109
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H16-N3-O14-P3
MOLECULAR WEIGHT :
483.19
WISWESSER LINE NOTATION :
T6NVNJ DZ A- BT5OTJ BOPQQO COPQQO D1OPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
100 umol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 425,1,1976
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