Cytarabine triphosphate

Modify Date: 2024-01-11 11:31:21

Cytarabine triphosphate structure	Common Name	Cytarabine triphosphate
	CAS Number	13191-15-6	Molecular Weight	481.18400
	Density	2.5g/cm3	Boiling Point	849.2ºC at 760mmHg
	Molecular Formula	C₁₀H₁₈N₃O₁₃P₃	Melting Point	N/A
	MSDS	N/A	Flash Point	467.4ºC

Use of Cytarabine triphosphate

Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].

Name	4-Amino-1-[5-O-(hydroxy{[hydroxy(phosphonomethyl)phosphoryl]oxy}p hosphoryl)-β-D-arabinofuranosyl]-2(1H)-pyrimidinone

Description	Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
References	[1]. Anderson E, et, al. Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia. Exp Hematol. 2019 Jun;74:13-18.e3.

Density	2.5g/cm3
Boiling Point	849.2ºC at 760mmHg
Molecular Formula	C₁₀H₁₈N₃O₁₃P₃
Molecular Weight	481.18400
Flash Point	467.4ºC
Exact Mass	481.00500
PSA	291.61000
Index of Refraction	1.638

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5590000

CHEMICAL NAME :: Cytosine, 1-beta-D-arabinofuranosyl-, 5'-(tetrahydrogen triphosphate)

CAS REGISTRY NUMBER :: 13191-15-6

LAST UPDATED :: 199109

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H16-N3-O14-P3

MOLECULAR WEIGHT :: 483.19

WISWESSER LINE NOTATION :: T6NVNJ DZ A- BT5OTJ BOPQQO COPQQO D1OPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 100 umol/L

REFERENCE :: BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 425,1,1976

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ara-C triphosphate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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