- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Pumosetrag Hydrochloride
- Price:
- Purity: 99.0%
- Stocking Period: 10 Day
- Contact: Huang
- DC Chemicals Limited
- China
- Product Name: MKC-733
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: MKC-733
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
194093-42-0
194093-42-0 structure
- Name: Pumosetrag Hydrochloride
- Chemical Name: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-oxo-4H-thieno[3,2-b]pyridine-6-carboxamide,hydrochloride
- CAS Number: 194093-42-0
- Molecular Formula: C15H18ClN3O2S
- Molecular Weight: 339.840
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-12-29 18:59:48
- Modify Date: 2024-01-09 11:24:45
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Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
| Name | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-oxo-4H-thieno[3,2-b]pyridine-6-carboxamide,hydrochloride |
|---|---|
| Synonyms |
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride (1:1)
Pumosetraghydrochloride (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-7-oxo-4,7-dihydrothieno-[3,2-b]pyridine-6-carboxamide hydrochloride UNII-UVW44TKU66 (R)-N-(3-Quinuclidinyl)-7-oxo-dihydrothieno(3,2b)pyridine-6-carboxamide hydrochloride (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride Thieno[3,2-b]pyridine-6-carboxamide, N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4,7-dihydro-7-oxo-, hydrochloride (1:1) DPP 733 (R)-N-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxothieno[3,2-b]pyridine-6-carboxamide monohydrochloride (R)-N-(3-quinuclidinyl)-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride Pumosetrag Hydrochloride |
| Description | Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. |
|---|---|
| Related Catalog | |
| Target |
5-HT3[1] |
| In Vivo | Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors[1]. Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit[2]. |
| References |
| Boiling Point | 529.9ºC at 760mmHg |
|---|---|
| Molecular Formula | C15H18ClN3O2S |
| Molecular Weight | 339.840 |
| Flash Point | 274.3ºC |
| Exact Mass | 339.080811 |
| PSA | 96.93000 |
| LogP | 2.72830 |
| Vapour Pressure | 2.59E-11mmHg at 25°C |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
|---|