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63307-63-1

63307-63-1 structure
63307-63-1 structure
  • Name: [D- MET2 , PRO5 ]-ENKEPHALINAMIDE
  • Chemical Name: 1-[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxamide
  • CAS Number: 63307-63-1
  • Molecular Formula: C30H40N6O6S
  • Molecular Weight: 612.74000
  • Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
  • Create Date: 2017-04-26 19:23:33
  • Modify Date: 2024-01-12 16:17:52
  • (D-Met2,Pro5)-Enkephalinamide is a highly potent opiate agonist, and shows antinociceptive activity[1][2][3].
Name 1-[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxamide
Synonyms H-Tyr-D-Met-Gly-Phe-Pro-NH2
L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-L-proline amide
Tyr-D-Met-Gly-Phe-Pro-NH2
Description (D-Met2,Pro5)-Enkephalinamide is a highly potent opiate agonist, and shows antinociceptive activity[1][2][3].
Related Catalog
In Vivo (D-Met2,Pro5)-Enkephalinamide (intravenous injection; 0.25 and 0.5 mg/kg; once) leads to the decreasement of prolactin (PRL) secretion in lactating rats[2]. Animal Model: Wistar lactating rats[2] Dosage: 0.25 and 0.5 mg/kg Administration: Intravenous injection; 0.25 and 0.5 mg/kg; once Result: Decreased plasma PRL levels 15 min after the administration in continuously lactating rats. Produced a marked depression in plasma PRL concentration in non-deprived lactating mothers.
Density 1.31g/cm3
Boiling Point 1065ºC at 760 mmHg
Molecular Formula C30H40N6O6S
Molecular Weight 612.74000
Flash Point 597.9ºC
Exact Mass 612.27300
PSA 233.71000
LogP 4.12870
Index of Refraction 1.616

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TW3583000
CHEMICAL NAME :
L-Prolinamide, L-tyrosyl-D-methionylglycyl-L-phenylalanyl-
CAS REGISTRY NUMBER :
63307-63-1
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C30-H40-N6-O6-S
MOLECULAR WEIGHT :
612.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
278 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Behavioral - antipsychotic Behavioral - alteration of classical conditioning
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,641,1987
66864-05-9 structure

66864-05-9

~%

63307-63-1 structure

63307-63-1
Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
13734-34-4 structure

13734-34-4

~%

63307-63-1 structure

63307-63-1
Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
38017-89-9 structure

38017-89-9

~%

63307-63-1 structure

63307-63-1
Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
70777-31-0 structure

70777-31-0

~%

63307-63-1 structure

63307-63-1
Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
108329-67-5 structure

108329-67-5

~%

63307-63-1 structure

63307-63-1
Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
82558-39-2 structure

82558-39-2

~%

63307-63-1 structure

63307-63-1
Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
74825-83-5 structure

74825-83-5

~%

63307-63-1 structure

63307-63-1
Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177
69612-72-2 structure

69612-72-2

~%

63307-63-1 structure

63307-63-1
Literature: Audigier; Mazarguil; Gout; Cros European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177

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title: CAS No. 63307-63-1 | Chemsrc address: https://m.chemsrc.com/en/baike/910181.html

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