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  • DC Chemicals Limited
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  • Product Name: 4-CMTB
  • Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

300851-67-6

300851-67-6 structure
300851-67-6 structure
  • Name: 4-CMTB
  • Chemical Name: 2-(4-Chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide
  • CAS Number: 300851-67-6
  • Molecular Formula: C14H15ClN2OS
  • Molecular Weight: 294.80000
  • Catalog: Research Areas Others
  • Create Date: 2018-12-29 23:44:15
  • Modify Date: 2024-01-14 09:39:56
  • 4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38)[1].

Name 2-(4-Chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide
Description 4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38)[1].
Related Catalog
In Vitro 4-CMTB is both a direct agonist and a positive allosteric modulator of the action of short-chain free fatty acids. 4-CMTB modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2)[1][2].
References

[1]. Smith NJ, et al. Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol. 2011;80(1):163-173.

[2]. Milligan G, Stoddart LA, Smith NJ. Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br J Pharmacol. 2009;158(1):146-153.

Molecular Formula C14H15ClN2OS
Molecular Weight 294.80000
Exact Mass 294.05900
PSA 73.72000
LogP 4.82430
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
RIDADR NONH for all modes of transport