325457-99-6
325457-99-6 structure
- Name: ICA 110381
- Chemical Name: 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
- CAS Number: 325457-99-6
- Molecular Formula: C12H8Cl2N2O
- Molecular Weight: 267.11
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2018-12-31 22:57:01
- Modify Date: 2024-01-03 18:08:26
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ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].
| Name | 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide |
|---|---|
| Synonyms | 2-acetamido-6-chloropyridine |
| Description | ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1] IC50: 15 μM (KCNQ1)[1] |
| References |
| Molecular Formula | C12H8Cl2N2O |
|---|---|
| Molecular Weight | 267.11 |
| Exact Mass | 266.00100 |
| PSA | 41.99000 |
| LogP | 3.71370 |
