112448-39-2

112448-39-2 structure

Name: 3'-Demethylnobiletin
Chemical Name: 2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
CAS Number: 112448-39-2
Molecular Formula: C₂₀H₂₀O₈
Molecular Weight: 388.36800
Catalog: Research Areas Cancer
Create Date: 2017-07-15 14:11:16
Modify Date: 2024-01-10 13:33:17
3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2].

Name	2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
Synonyms	4H-1-Benzopyran-4-one,2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxy 3'-hydroxy-5,6,7,8,4'-pentamethoxyflavone 7-Hydroxy-3',4',5,6-tetramethoxyflavone 3'-Demethylnobiletin

Description	3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Murakami A, et al. In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci Biotechnol Biochem. 2001 Jan;65(1):194-7. [2]. Sp N, et al. Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER⁺ Breast Cancer Cells. Int J Mol Sci. 2017 Apr 30;18(5). pii: E935.