3'-Demethylnobiletin

Modify Date: 2024-01-10 13:33:17

3'-Demethylnobiletin Structure
3'-Demethylnobiletin structure
Common Name 3'-Demethylnobiletin
CAS Number 112448-39-2 Molecular Weight 388.36800
Density 1.304g/cm3 Boiling Point 613.8ºC at 760 mmHg
Molecular Formula C20H20O8 Melting Point 170-171 ºC
MSDS N/A Flash Point 218.8ºC

 Use of 3'-Demethylnobiletin


3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2].

 Names

Name 2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
Synonym More Synonyms

 3'-Demethylnobiletin Biological Activity

Description 3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2].
Related Catalog
References

[1]. Murakami A, et al. In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci Biotechnol Biochem. 2001 Jan;65(1):194-7.

[2]. Sp N, et al. Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells. Int J Mol Sci. 2017 Apr 30;18(5). pii: E935.

 Chemical & Physical Properties

Density 1.304g/cm3
Boiling Point 613.8ºC at 760 mmHg
Melting Point 170-171 ºC
Molecular Formula C20H20O8
Molecular Weight 388.36800
Flash Point 218.8ºC
Exact Mass 388.11600
PSA 96.59000
LogP 3.20860
Vapour Pressure 1.17E-15mmHg at 25°C
Index of Refraction 1.582
Water Solubility Practically insoluble (0.039 g/L) (25 ºC)

 Synonyms

4H-1-Benzopyran-4-one,2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxy
3'-hydroxy-5,6,7,8,4'-pentamethoxyflavone
7-Hydroxy-3',4',5,6-tetramethoxyflavone
3'-Demethylnobiletin