245443-52-1

245443-52-1 structure

Name: PAR-4 (1-6) amide (mouse) trifluoroacetate salt
Chemical Name: h-gly-tyr-pro-gly-lys-phe-nh2
CAS Number: 245443-52-1
Molecular Formula: C₃₃H₄₆N₈O₇
Molecular Weight: 666.76800
Catalog: Peptides
Create Date: 2018-12-28 10:14:44
Modify Date: 2024-01-07 13:31:06
Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).

Name	h-gly-tyr-pro-gly-lys-phe-nh2
Synonyms	par-4 agonist amide gypgkfamide gypgkf-nh2 protease-activated receptor-4 agonist amide h2n-gypgkf-amide GLY-TYR-PRO-GLY-LYS-PHE-NH2 Protease-Activated Receptor-4

Description	Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR) Research Areas >> Others Peptides
In Vitro	GYPGKF-NH2 significantly reduces the agonistic potency of AYPGKF-NH2 by 25-fold[1]. GYPGKF-NH2 (500 μM) does not cause contraction or relaxation of the guinea pig IAS strips[2].
References	[1]. Moschonas IC, et al. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets. 2017 Mar 7:1-10. doi: 10.1080/09537104.2017.1282607. [Epub ahead of print] [2]. Huang SC, et al. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014 Feb 10;189:46-50.