PAR-4 (1-6) amide (mouse) trifluoroacetate salt

Modify Date: 2024-01-07 13:31:06

PAR-4 (1-6) amide (mouse) trifluoroacetate salt Structure
PAR-4 (1-6) amide (mouse) trifluoroacetate salt structure
Common Name PAR-4 (1-6) amide (mouse) trifluoroacetate salt
CAS Number 245443-52-1 Molecular Weight 666.76800
Density N/A Boiling Point N/A
Molecular Formula C33H46N8O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PAR-4 (1-6) amide (mouse) trifluoroacetate salt


Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).

 Names

Name h-gly-tyr-pro-gly-lys-phe-nh2
Synonym More Synonyms

  Biological Activity

Description Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).
Related Catalog
In Vitro GYPGKF-NH2 significantly reduces the agonistic potency of AYPGKF-NH2 by 25-fold[1]. GYPGKF-NH2 (500 μM) does not cause contraction or relaxation of the guinea pig IAS strips[2].
References

[1]. Moschonas IC, et al. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets. 2017 Mar 7:1-10. doi: 10.1080/09537104.2017.1282607. [Epub ahead of print]

[2]. Huang SC, et al. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014 Feb 10;189:46-50.

 Chemical & Physical Properties

Molecular Formula C33H46N8O7
Molecular Weight 666.76800
Exact Mass 666.34900
PSA 252.07000
LogP 1.91440
Storage condition 2-8℃

 Synonyms

par-4 agonist amide
gypgkfamide
gypgkf-nh2
protease-activated receptor-4 agonist amide
h2n-gypgkf-amide
GLY-TYR-PRO-GLY-LYS-PHE-NH2
Protease-Activated Receptor-4
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