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402473-54-5

402473-54-5 structure
402473-54-5 structure
  • Name: ONO-AE3-208
  • Chemical Name: 4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid
  • CAS Number: 402473-54-5
  • Molecular Formula: C24H21FN2O3
  • Molecular Weight: 404.434
  • Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
  • Create Date: 2018-12-20 16:08:18
  • Modify Date: 2024-01-12 19:39:13
  • ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.
Name 4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid
Synonyms 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid
ONO AE3 208
4-[4-cyano-2-[2-(4-fluoro-1-naphthyl)propanoylamino]phenyl]butanoic acid
4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid
ONO-AE3-208||ONO AE3 208
4-(4-Cyano-2-{[2-(4-fluoro-1-naphthyl)propanoyl]amino}phenyl)butanoic acid
Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-
ONO-AE3-208
Description ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.
Related Catalog
Target

EP4

In Vitro ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation[1]. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208[2].
In Vivo ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice[1]. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls[3].
References

[1]. Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18.

[2]. Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8.

[3]. Xu S, et al. Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice. Zhonghua Nan Ke Xue. 2014 Aug;20(8):684-9.

[4]. Thieme K, et al. EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease. Sci Rep. 2017 Jun 13;7(1):3442.
Density 1.3±0.1 g/cm3
Boiling Point 662.4±55.0 °C at 760 mmHg
Molecular Formula C24H21FN2O3
Molecular Weight 404.434
Flash Point 354.4±31.5 °C
Exact Mass 404.153625
PSA 90.19000
LogP 4.56
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.637
Storage condition 2-8℃

Chemsrc provides CAS#:402473-54-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 402473-54-5 | Chemsrc address: https://m.chemsrc.com/en/baike/92347.html

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