1009104-85-1
1009104-85-1 structure
- Name: SMAD3
- Chemical Name: SIS3 free base
- CAS Number: 1009104-85-1
- Molecular Formula: C28H27N3O3
- Molecular Weight: 453.532
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
- Create Date: 2016-04-03 12:27:39
- Modify Date: 2024-01-08 19:31:52
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SIS3 free base is a potent and selective inhibitor of TGF- beta1-induced Smad3 phosphorylation with an IC50 of 3 μM. SIS3 free base increases luciferase activity of p3TP-lux by abrogating the overexpression of constitutively active form of ALK-5[1].
| Name | SIS3 free base |
|---|---|
| Synonyms |
IN1090
SMAD3 Inhibtor,SIS 3 (2E)-1-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one 2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-, (2E)- 1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one |
| Description | SIS3 free base is a potent and selective inhibitor of TGF- beta1-induced Smad3 phosphorylation with an IC50 of 3 μM. SIS3 free base increases luciferase activity of p3TP-lux by abrogating the overexpression of constitutively active form of ALK-5[1]. |
|---|---|
| Related Catalog | |
| Target |
Smad3, ALK-5[1] |
| In Vitro | SIS3 free base (0.3-10 μM; for 1 hour) attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4[1]. Western Blot Analysis[1] Cell Line: Human dermal fibroblasts Concentration: 0.3, 1, 3, 10 μM Incubation Time: For 1 hour Result: Attenuated the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 721.8±60.0 °C at 760 mmHg |
| Molecular Formula | C28H27N3O3 |
| Molecular Weight | 453.532 |
| Flash Point | 390.3±32.9 °C |
| Exact Mass | 453.205231 |
| PSA | 56.59000 |
| LogP | 5.28 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.628 |