220662-95-3

220662-95-3 structure

Name: RJR 2403 oxalate
Chemical Name: (E)-N-methyl-4-pyridin-3-ylbut-3-en-1-amine,oxalic acid
CAS Number: 220662-95-3
Molecular Formula: C₁₂H₁₆N₂O₄
Molecular Weight: 252.26600
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2018-06-27 16:32:37
Modify Date: 2024-01-02 18:44:37
Rivanicline oxalate (RJR-2403 oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).

Name	(E)-N-methyl-4-pyridin-3-ylbut-3-en-1-amine,oxalic acid
Synonyms	Rivanicline oxalate CS-0531 RJR-2403 oxalate RJR-2403 oxalate\|\|Rivanicline oxalate\|RJR 2403 oxalate RJR-2403 (oxalate)

Description	Rivanicline oxalate (RJR-2403 oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
References	[1]. Bencherif M, et al. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21. [2]. Lippiello PM, et al. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9. [3]. Damaj MI, et al. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.