69819-86-9

69819-86-9 structure

Name: ZIO 101
Chemical Name: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CAS Number: 69819-86-9
Molecular Formula: C₁₂H₂₂AsN₃O₆S
Molecular Weight: 411.30600
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-12-22 18:47:03
Modify Date: 2025-08-25 10:16:33
Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1].

Name	(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Synonyms	Darinaparsin ZIO-101-C UNII-9XX54M675G Zinapar SGLU1 ZIO-101 SP-02L Darinaparsin (USAN) DMAs(III)G

Description	Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations[1].
In Vivo	Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells[1].
References	[1]. Nitu Bansal, et al. Darinaparsin inhibits prostate tumor-initiating cells and Du145 xenografts and is an inhibitor of hedgehog signaling. Mol Cancer Ther. 2015 Jan;14(1):23-30.