202822-23-9

202822-23-9 structure

Name: BMS-195270
Chemical Name: 2-(5-chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one
CAS Number: 202822-23-9
Molecular Formula: C₁₅H₉ClF₃N₃O₂
Molecular Weight: 355.70
Catalog: Research Areas Others
Create Date: 2016-01-12 20:07:21
Modify Date: 2024-02-05 23:15:30
BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux[1].

Name	2-(5-chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one
Synonyms	unii-20um0t170j

Description	BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	BMS-195270 (3 μM) 在灌注体积为 0.2-1.3 毫升时显著降低了外源性大鼠整体膀胱模型的压力，同时抑制了自发收缩[1]。 BMS-195270 (2.8 mM) 导致秀丽线虫的成虫表现出 Egl-d 表型，以及缓慢或停止的咽部泵动 (Eat) 和不协调的运动 (Unc)[1]。 BMS-195270 抑制 HEK293 细胞对毛囊素受体激动剂卡巴胆碱 (HY-B1208) 的反应，EC50 为 2 μM[1]。 BMS-195270 抑制钙流，即使内源性钙通道被失活，也保留了抑制活性[1]。
References	[1]. Fitzgerald K, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57.