BMS-195270
Modify Date: 2024-02-05 23:15:30
BMS-195270 structure
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Common Name | BMS-195270 | ||
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| CAS Number | 202822-23-9 | Molecular Weight | 355.70 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H9ClF3N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS-195270BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux[1]. |
| Name | 2-(5-chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one |
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| Synonym | More Synonyms |
| Description | BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux[1]. |
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| Related Catalog | |
| In Vitro | BMS-195270 (3 μM) 在灌注体积为 0.2-1.3 毫升时显著降低了外源性大鼠整体膀胱模型的压力，同时抑制了自发收缩[1]。 BMS-195270 (2.8 mM) 导致秀丽线虫的成虫表现出 Egl-d 表型，以及缓慢或停止的咽部泵动 (Eat) 和不协调的运动 (Unc)[1]。 BMS-195270 抑制 HEK293 细胞对毛囊素受体激动剂卡巴胆碱 (HY-B1208) 的反应，EC50 为 2 μM[1]。 BMS-195270 抑制钙流，即使内源性钙通道被失活，也保留了抑制活性[1]。 |
| References |
| Molecular Formula | C15H9ClF3N3O2 |
|---|---|
| Molecular Weight | 355.70 |
| Exact Mass | 355.03400 |
| PSA | 70.91000 |
| LogP | 3.60540 |
| unii-20um0t170j |