1034474-19-5
1034474-19-5 structure
- Name: 3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile
- Chemical Name: 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile
- CAS Number: 1034474-19-5
- Molecular Formula: C21H12Cl2N6O
- Molecular Weight: 435.266
- Create Date: 2017-02-27 12:12:22
- Modify Date: 2024-02-15 20:54:10
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MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.
| Name | 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile |
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| Description | MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections. |
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| In Vitro | MK-6186 showed FCs of <10 against EFV or etravirine (ETR) and the mutant viruses containing mutations selected by EFV or ETR were sensitive to MK-6186 (FCs of <10).[1] |
| References | 1. Lu M, et al. Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2012 Jun;56(6):3324-35. |
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 656.4±55.0 °C at 760 mmHg |
| Molecular Formula | C21H12Cl2N6O |
| Molecular Weight | 435.266 |
| Flash Point | 350.8±31.5 °C |
| Exact Mass | 434.044952 |
| PSA | 92.41000 |
| LogP | 4.86 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.763 |