3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile
Modify Date: 2024-02-15 20:54:10
![3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile Structure](https://www.chemsrc.com/caspic/284/1034474-19-5.png)
3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile structure
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Common Name | 3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile | ||
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| CAS Number | 1034474-19-5 | Molecular Weight | 435.266 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 656.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C21H12Cl2N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 350.8±31.5 °C | |
Use of 3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrileMK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections. |
| Name | 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile |
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| Description | MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections. |
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| In Vitro | MK-6186 showed FCs of <10 against EFV or etravirine (ETR) and the mutant viruses containing mutations selected by EFV or ETR were sensitive to MK-6186 (FCs of <10).[1] |
| References | 1. Lu M, et al. Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2012 Jun;56(6):3324-35. |
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 656.4±55.0 °C at 760 mmHg |
| Molecular Formula | C21H12Cl2N6O |
| Molecular Weight | 435.266 |
| Flash Point | 350.8±31.5 °C |
| Exact Mass | 434.044952 |
| PSA | 92.41000 |
| LogP | 4.86 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.763 |