3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile

Modify Date: 2025-08-31 19:59:21

3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile structure	Common Name	3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile
	CAS Number	1034474-19-5	Molecular Weight	435.266
	Density	1.6±0.1 g/cm3	Boiling Point	656.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₂Cl₂N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	350.8±31.5 °C

Use of 3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile

MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.

Name	3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-indazol-4-yl]oxy}benzonitrile

Description	MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.
In Vitro	MK-6186 showed FCs of <10 against EFV or etravirine (ETR) and the mutant viruses containing mutations selected by EFV or ETR were sensitive to MK-6186 (FCs of <10).[1]
References	1. Lu M, et al. Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2012 Jun;56(6):3324-35.

Density	1.6±0.1 g/cm3
Boiling Point	656.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₂Cl₂N₆O
Molecular Weight	435.266
Flash Point	350.8±31.5 °C
Exact Mass	434.044952
PSA	92.41000
LogP	4.86
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.763

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