85286-38-0

85286-38-0 structure

Name: (D-Thr2)-Leu-Enkephalin-Thr
Chemical Name: [D-Thr2,Leu5]enkephalin-Thr
CAS Number: 85286-38-0
Molecular Formula: C₃₄H₄₈N₆O₁₀
Molecular Weight: 700.779
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2016-07-28 14:42:25
Modify Date: 2024-01-09 20:11:34
Deltakephalin is a potent, selective opiate δ-receptor agonist. Deltakephalin has analgesic properties[1].

Name	[D-Thr2,Leu5]enkephalin-Thr
Synonyms	D-Allothreonine, L-tyrosyl-D-threonylglycyl-L-phenylalanyl-L-leucyl- (D-Thr2)-Leu-Enkephalin-Thr (D-Thr2)-Leu-Enkephalin-Thr, DTLET, Deltakephalin Tyr-D-Thr-Gly-Phe-Leu-Thr L-Tyrosyl-D-threonylglycyl-L-phenylalanyl-L-leucyl-D-allothreonine

Description	Deltakephalin is a potent, selective opiate δ-receptor agonist. Deltakephalin has analgesic properties[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vivo	Deltakephalin (2 nM/rat; ICV; once) produces a pronounced analgesia in rats[1]. Animal Model: Male spontaneously hypertensive rats (SHR/n/Ibm) and male Wistar Albino Glaxo rats (WAG) (250-300 g)[1] Dosage: 2 nM/rat Administration: Intracerebroventrical injection Result: Produced pronounced analgesia in male spontaneously hypertensive rats with EC50 values of 0.57 and 0.88 nM for the tail flick test and the tail compression test, respectively.