1217854-79-9

1217854-79-9 structure

Name: D-(-)-4-Hydroxyphenyl-d4-glycine
Chemical Name: D-(-)-4-Hydroxyphenyl-d4-glycine
CAS Number: 1217854-79-9
Molecular Formula: C₈H₅D₄NO₃
Molecular Weight: 171.18700
Catalog: Research Areas Others
Create Date: 2017-04-05 07:04:36
Modify Date: 2024-01-01 22:13:28
D-4-Hydroxyphenylglycine-d4 (D-(-)-4-Hydroxyphenylglycine-d4) is the deuterium labeled D-4-Hydroxyphenylglycine. D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1].

Name	D-(-)-4-Hydroxyphenyl-d4-glycine
Synonyms	(2R)-2-amino-2-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)acetic acid

Description	D-4-Hydroxyphenylglycine-d4 (D-(-)-4-Hydroxyphenylglycine-d4) is the deuterium labeled D-4-Hydroxyphenylglycine. D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yu H, et al. Efficient biocatalytic production of D-4-hydroxyphenylglycine by whole cells of recombinant Ralstonia pickettii. Folia Microbiol (Praha). 2009;54(6):509-515.