D-(-)-4-Hydroxyphenyl-d4-glycine

Modify Date: 2024-01-01 22:13:28

D-(-)-4-Hydroxyphenyl-d4-glycine Structure
D-(-)-4-Hydroxyphenyl-d4-glycine structure
Common Name D-(-)-4-Hydroxyphenyl-d4-glycine
CAS Number 1217854-79-9 Molecular Weight 171.18700
Density N/A Boiling Point N/A
Molecular Formula C8H5D4NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of D-(-)-4-Hydroxyphenyl-d4-glycine


D-4-Hydroxyphenylglycine-d4 (D-(-)-4-Hydroxyphenylglycine-d4) is the deuterium labeled D-4-Hydroxyphenylglycine. D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1].

 Names

Name D-(-)-4-Hydroxyphenyl-d4-glycine
Synonym More Synonyms

 D-(-)-4-Hydroxyphenyl-d4-glycine Biological Activity

Description D-4-Hydroxyphenylglycine-d4 (D-(-)-4-Hydroxyphenylglycine-d4) is the deuterium labeled D-4-Hydroxyphenylglycine. D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Yu H, et al. Efficient biocatalytic production of D-4-hydroxyphenylglycine by whole cells of recombinant Ralstonia pickettii. Folia Microbiol (Praha). 2009;54(6):509-515.

 Chemical & Physical Properties

Molecular Formula C8H5D4NO3
Molecular Weight 171.18700
Exact Mass 171.08300
PSA 83.55000
LogP 1.17690

 Synonyms

(2R)-2-amino-2-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)acetic acid