14270-73-6
14270-73-6 structure
- Name: 5'-Trt-2'-dU
- Chemical Name: 5'-O-Trityl-2'-deoxyuridine
- CAS Number: 14270-73-6
- Molecular Formula: C28H26N2O5
- Molecular Weight: 470.52
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
- Create Date: 2018-12-22 12:30:01
- Modify Date: 2024-01-17 15:19:48
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5’-O-Triphenylmethyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
| Name | 5'-O-Trityl-2'-deoxyuridine |
|---|---|
| Synonyms |
1-[(2R,4S,5R)-4-hydroxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
5'-Trt-2'-dU |
| Description | 5’-O-Triphenylmethyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3g/cm3 |
|---|---|
| Melting Point | 204-205 °C |
| Molecular Formula | C28H26N2O5 |
| Molecular Weight | 470.52 |
| Exact Mass | 470.18400 |
| PSA | 93.55000 |
| LogP | 3.19370 |
| Index of Refraction | 1.63 |
| HS Code | 2934999090 |
|---|
|
~97%
14270-73-6 |
| Literature: Nguyen, Corinne; Kasinathan, Ganasan; Leal-Cortijo, Isabel; Musso-Buendia, Alexander; Kaiser, Marcel; Brun, Reto; Ruiz-Perez, Luis M.; Johansson, Nils G.; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5942 - 5954 |
|
~96%
14270-73-6 |
| Literature: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Patent: EP1674104 A1, 2006 ; Location in patent: Page/Page column 11; 19 ; |
|
~39%
14270-73-6 |
| Literature: Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255 |
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |