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3836-23-5

3836-23-5 structure
3836-23-5 structure
  • Name: Norethisterone enanthate
  • Chemical Name: Norethisterone enanthate
  • CAS Number: 3836-23-5
  • Molecular Formula: C27H38O3
  • Molecular Weight: 410.589
  • Catalog: Research Areas Endocrinology
  • Create Date: 2018-07-12 09:42:53
  • Modify Date: 2024-01-05 17:59:04
  • Norethisterone enanthate is a long-acting parenteral progestogen. Norethisterone enanthate is orally active[1][2][3].
Name Norethisterone enanthate
Synonyms [(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] heptanoate
17α-Ethynyl-19-nortestosterone 17-heptanoate
MFCD01741291
17-α-Ethynyl-17-β-heptanoyloxy-4-estren-3-one
17α-Ethynyl-19-nortestosterone enanthate
Heptanoic acid, (17β)-17-ethynyl-3-oxoestr-4-en-17-yl ester
Noristerat
Norethisterone enanthate
17α-Ethynyl-17β-heptanoyloxy-4-estren-3-one
EINECS 223-326-7
NEE
Norethisterone oenanthate
19-Nor-17α-pregn-4-en-20-yn-3-one, 17-hydroxy-, heptanoate (8CI)
(17α)-17-((1-Oxoheptyl)oxy)-19-norpregn-4-en-20-yn-3-one
Norlutin enanthate
(17α)-3-Oxo-19-norpregn-4-en-20-yn-17-yl heptanoate
Norigest
19-Nor-17α-pregn-4-en-20-yn-3-one, 17-hydroxy-, heptanoate
17-β-Heptanoyloxy-17-α-ethynyl-4-oestren-3-one
Norethindrone enanthate
Description Norethisterone enanthate is a long-acting parenteral progestogen. Norethisterone enanthate is orally active[1][2][3].
Related Catalog
In Vitro Norethisterone enanthate can be used as an intramuscular contraceptive agent[1].
In Vivo Norethisterone enanthate (20-60 mg; p.o.;5 days) inhibits fertility in female rats[3]. Animal Model: Female adult albino rats (Wistar/NIN) weighing around 160-180 g[1] Dosage: 20, 30, 40, 50, 60 mg Administration: P.o.; 5 days Result: A significant reduction in fertility was seen with doses 30 to 60 mg in rats.
References

[1]. Kesserü-Koós E, Larrañaga-Legufa A, Hurtado-Koo H, Scharff HJ. Fertility control with norethindrone enanthate, a long-acting parenteral progestogen. Acta Eur Fertil. 1973;4(4):203‐221.

[2]. Ravinder P, Shatrugna V, Nair KM, Sivakumar B. Pharmacokinetics of orally administered norethisterone enanthate in rabbit, monkey, and women. Contraception. 1997;55(6):373‐379.

[3]. Ravinder P, Nair KM, Sivakumar B. Biological efficacy and plasma norethisterone levels of orally administered norethisterone enanthate in rat and hamster. Indian J Physiol Pharmacol. 1998;42(4):485‐490.
Density 1.1±0.1 g/cm3
Boiling Point 515.3±50.0 °C at 760 mmHg
Molecular Formula C27H38O3
Molecular Weight 410.589
Flash Point 219.0±30.2 °C
Exact Mass 410.282104
PSA 43.37000
LogP 6.64
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.540
Storage condition 2~8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC8973000
CHEMICAL NAME :
19-Nor-17-alpha-pregnen-20-ynone, 17-beta-heptanoyloxy-
CAS REGISTRY NUMBER :
3836-23-5
BEILSTEIN REFERENCE NO. :
3176529
LAST UPDATED :
199612
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C27-H38-O3
MOLECULAR WEIGHT :
410.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - increased intraocular pressure
REFERENCE :
ADVPB4 Advances in Planned Parenthood. (Excerpta Medica, Inc., POB 3085, Princeton, NJ 08540) V.1-16, 1967-81. Volume(issue)/page/year: 8,103,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 12(4),13,1992 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7000 mg/kg/70W
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors
REFERENCE :
36PYAS "Pharmacology of Steroid Contraceptive Drugs," Garattini, S. and H.W. Berendes, eds., New York, Raven Press, 1977 Volume(issue)/page/year: -,163,1977 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
4 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,21,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
4 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
AZOGBS Australian & New Zealand Journal of Obstetrics & Gynaecology. (254 Albert St., E. Melbourne, Vic., Australia) V.1- 1961- Volume(issue)/page/year: 11,233,1971
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
4 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 13,415,1968
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
24 mg/kg
SEX/DURATION :
female 6 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 25,333,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
12 mg/kg
SEX/DURATION :
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 69,93,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
150 mg/kg
SEX/DURATION :
female 14-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 71,448,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
48 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 24,61,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
100 mg/kg
SEX/DURATION :
female 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 25,151,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
3483 ug/kg
SEX/DURATION :
male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974- Volume(issue)/page/year: 15,333,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
4 mg/kg
SEX/DURATION :
female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 12,529,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
475 mg/kg
SEX/DURATION :
female 4-23 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - stillbirth
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 89,701,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
5038 ug/kg
SEX/DURATION :
female 56 day(s) pre-mating female 1-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 19,416,1981
Hazard Codes Xi

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