434-07-1

434-07-1 structure

Name: Oxymetholone
Chemical Name: oxymetholone
CAS Number: 434-07-1
Molecular Formula: C₂₁H₃₂O₃
Molecular Weight: 332.477
Catalog: API Hormone and endocrine-regulating drugs Androgen and anabolic hormone drugs
Create Date: 2018-07-08 16:42:35
Modify Date: 2026-06-30 18:55:31

Name	oxymetholone
Synonyms	17-beta-hydroxy-2-(hydroxymethylene)-17-methyl-5-alpha-androstan-3-on Oximetolona Pavisoid 17-hydroxy-2-(hydroxymethylene)-17-methyl-,(alpha,17beta)-androstan-3-on MFCD00869395 5ALPHA-ANDROSTAN-17ALPHA-METHYL-17BETA-OL-2-HYDROXYMETHYLENE-3-ONE Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17-methyl-, (5alpha,17beta) Anasteronal Protanabol 17-alpha-Methyl-2-hydroxymethylene-17-hydroxy-5-alpha-androstan-3-one Stanozolol impurity B 5-alpha-Androstan-3-one, 17-beta-hydroxy-2-(hydroxymethylene)-17-methyl OxyMetholone (Anadrol) Zenalosyn 17BETA-HYDROXY-2-(HYDROXYMETHYLENE)-17-METHYL-5ALPHA-ANDROSTAN-3-ONE ANASTERONE Raboral (2Z,8R,9S,10S,13S,14S,17R)-17-hydroxy-2-(hydroxymethylidene)-10,13,17-trimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one oxymethalone 2-Hydroxymethylene-17a-methylandrostan-17b-ol-3-one Pdroyd Oxymetholon Anadrol 4,5-Dihydro-2-hydroxymethylene-17-alpha-methyltestosterone 17beta-hydroxy-2-(hydroxymethylene)-17-methyl-5alpha-androstan-3-on oximetholonium oxymetholone-deascheduleiii Anadrol Roboral Adroidin 17-beta-androstan-3-one,17-hydroxy-2-(hydroxymethylene)-17-methyl-5-alph 17-beta-Hydroxy-2-hydroxymethylene-17-alpha-methyl-3-androstanone (5α,17β)-17-Hydroxy-2-(hydroxyMethylene)-17-Methylandrostan-3-one ci406 17beta-Hydroxy-2-(hydroxymethylene)-17-methyl-5alpha-androstan-3-one Anasterone CI-406 (2Z,5S,8R,9S,10S,13S,14S,17S)-17-Hydroxy-2-(hydroxymethylene)-10,13,17-trimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one (2Z,5α,17β)-17-hydroxy-2-(hydroxymethylidene)-17-methylandrostan-3-one Anapolon (2Z,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxyméthylidène)-10,13,17-triméthylhexadécahydro-3H-cyclopenta[a]phénanthrén-3-one Oximetholonum Oxymethenolone Anasteron 17-Hydroxy-2-(hydroxymethylene)-17-methyl-5-alpha-17-beta-androst-3-one 4,5alpha-dihydro-2-hydroxymethylene-17alpha-methyltestosterone androstan-3-one,17-hydroxy-2-(hydroxymethylene)-17-methyl-,(5-alpha,17-beta 5-alpha,17-beta-Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17-methyl 17b-hydroxy-2-hydroxymethylene-17a-methyl-3-androstanone Synasteron 17-Hydroxy-2-hydroxymethylene-17-methyl-5-androstan-3-one (2Z,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethylidene)-10,13,17-trimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one (2Z,5α,17β)-17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one 17-beta-Hydroxy-2-(hydroxymethylene)-17-alpha-methyl-5-alpha-androstan-3-one 2-Hydroxymethylene-17a-methyl-17b-hydroxy-5a-androstan-3-one 4,5a-Dihydro-2-hydroxymethylene-17a-methyltestosterone EINECS 207-098-6 4,5-dihydro-2-hydroxymethylene-17-a-methyltestosterone Oximetholone Oxitosona-50 (2Z,5α,17β)-17-Hydroxy-2-(hydroxymethyliden)-17-methylandrostan-3-on Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17-methyl-, (5α,17β) 17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one Adroyd Anadroyd OxyMetholon 17-hydroxy-5-alpha-androstan-3-one 5-ALPHA-ANDROSTAN-2-HYDROXYMETHYLENE-17-ALPHA-METHYL-17-BETA-OL-3-ONE Becorel (5a,17b)-17-Hydroxy-2-(hydroxymethylene)-17-methylandrostan-3-one anapalon 3-c)(1,2,5)oxadiazol-17-ol,17-methyl-,(5-alpha,17-beta)-androstano( Androstano(2,3-c)(1,2,5)oxadiazol-17-ol, 17-methyl-, (5-alpha,17-beta) Plenastril (2Z,5S,8R,9S,10S,13S,14S,17S)-17-Hydroxy-2-(hydroxymethyliden)-10,13,17-trimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-on

Density	1.2±0.1 g/cm3
Boiling Point	465.9±45.0 °C at 760 mmHg
Melting Point	172-180°C
Molecular Formula	C₂₁H₃₂O₃
Molecular Weight	332.477
Flash Point	249.7±25.2 °C
Exact Mass	332.235138
PSA	57.53000
LogP	4.22
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.590
Storage condition	2~8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8060000

CHEMICAL NAME :: 5-alpha,17-beta-Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17-methyl-

CAS REGISTRY NUMBER :: 434-07-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C21-H32-O3

MOLECULAR WEIGHT :: 332.53

WISWESSER LINE NOTATION :: L E5 B666 OVTJ A1 E1 FQ F1 P1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 46 mg/kg/14W-I

TOXIC EFFECTS :: Liver - liver function tests impaired

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5200 mg/kg/13W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 270 mg/kg/9W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 2336 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - jaundice (or hyperbilirubinemia) hepatocellular Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 3050 mg/kg/3Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 3735 mg/kg/3Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 17-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 128 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 150 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 28 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 14 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :: Micronucleus test

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 392,61,1997 *** REVIEWS *** IARC Cancer Review:Animal No Adequate Data IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,96,1987 TOXICOLOGY REVIEW BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 8,259,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6172 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 742 (estimated) No. of Female Employees: 359 (estimated)

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351-H361
Precautionary Statements	P281
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R40
Safety Phrases	S53-S22-S26-S36/37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	BV8060000
HS Code	2937290023

Precursor 0
DownStream 2
360-66-7 6251-57-6

HS Code	2937290023

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