82373-95-3

82373-95-3 structure

Name: 28-Homobrassinolide
Chemical Name: 6H-Benz[c]indeno[5,4-e]oxepin-6-one, 1-[(1S,2R,3R,4S)-4-ethyl-2,3-dihydroxy-1,5-dimethylhexyl]hexadecahydro-8,9-dihydroxy-10a,12a-dimethyl-, (1R,3aS,3bS,6aS,8S,9R,10aR,10bS,12aS)
CAS Number: 82373-95-3
Molecular Formula: C₂₉H₅₀O₆
Molecular Weight: 494.70400
Catalog: Research Areas Metabolic Disease
Create Date: 2016-03-16 07:54:18
Modify Date: 2024-01-03 16:24:18
28-Homobrassinolide is a phytosteroid. 28-Homobrassinolide can be used for the research of cholesterol and glucose homeostasis[1].

Name	6H-Benz[c]indeno[5,4-e]oxepin-6-one, 1-[(1S,2R,3R,4S)-4-ethyl-2,3-dihydroxy-1,5-dimethylhexyl]hexadecahydro-8,9-dihydroxy-10a,12a-dimethyl-, (1R,3aS,3bS,6aS,8S,9R,10aR,10bS,12aS)
Synonyms	(22R,23R)-2A,3A,22,23-TETRAHYDROXY-24-ETHYL-BETA-HOMO-7-OXA-5A-CHOLESTAN-6-ONE B-Homo-7-oxastigmastan-6-one, 2,3,22,23-tetrahydroxy-, (2α,3α,5α,22R,23R)- 28-Homobrassinolide 6H-Benz[c]indeno[5,4-e]oxepin-6-one, 1-(4-ethyl-2,3-dihydroxy-1,5-dimethylhexyl)hexadecahydro-8,9-dihydroxy-10a,12a-dimethyl-, [1R-[1α(1S,2R,3R,4S),3aβ,3bα,6aβ,8β,9β,10aα,10bβ,12aα]]- 28-Homobrassinolide

Description	28-Homobrassinolide is a phytosteroid. 28-Homobrassinolide can be used for the research of cholesterol and glucose homeostasis[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	28-Homobrassinolide (5-20 μM) 表明 HepG2 细胞中的葡萄糖利用以及 ABCA1 和 SREBP2 蛋白表达增加了 2 倍[1]。 28-Homobrassinolide 降低组织葡萄糖和胆固醇水平，增加胆固醇水平和组织己糖激酶活性[1]。 Cell Cytotoxicity Assay[1] Cell Line: HepG2 cells Concentration: 1 µM, 5 µM, 10 µM, 20 µM, 30 µM, 40 µM, and 80 µM Incubation Time: 24 h Result: The IC50 value of 40.57µM obtained by the MTT assay. Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 5, 10, and 20 μM Incubation Time: 12 h Result: Exhibited an increase in both ABCA1 and SREBP2 markers.
In Vivo	28-HB（1-20 μg/天；持续 6 周）显示高脂肪饮食喂养的 C57BL/6 小鼠的主动脉脂肪沉积和血清标志物水平显着降低[1]。 Animal Model: High-fat diet-fed C57BL/6 mice[1] Dosage: 1-20 μg/day Administration: For 6 weeks Result: Observed a significant decrease in lipid deposition.
References	[1]. Victor Mukherjee, et al. Phytosteroid 28-homobrassinolide targets cholesterol and glucose homeostasis implicating ABCA1 and SREBP role in regulation. Steroids. 2021 Jan;165:108756.