54898-41-8

54898-41-8 structure

Name: 8-Hydroxymethyl guanosine
Chemical Name: 8-(hydroxymethyl)guanosine
CAS Number: 54898-41-8
Molecular Formula: C₁₁H₁₅N₅O₆
Molecular Weight: 313.27
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2017-02-20 17:26:28
Modify Date: 2026-08-15 01:43:29
8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	8-(hydroxymethyl)guanosine
Synonyms	8-(Hydroxymethyl)guanosin 8-hydroxymethyl-guanosine Guanosine, 8-(hydroxymethyl) 8-hydroxymethylguanosine 2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-(hydroxymethyl)-1,9-dihydro-6H-purin-6-one

Description	8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.