8-Hydroxymethyl guanosine

Modify Date: 2024-04-02 11:15:18

8-Hydroxymethyl guanosine structure	Common Name	8-Hydroxymethyl guanosine
	CAS Number	54898-41-8	Molecular Weight	313.27
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₅N₅O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 8-Hydroxymethyl guanosine

8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	8-(hydroxymethyl)guanosine
Synonym	More Synonyms

Description	8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Molecular Formula	C₁₁H₁₅N₅O₆
Molecular Weight	313.27
Exact Mass	313.10200
PSA	179.74000

8-hydroxymethylguanosine

8-hydroxymethyl-guanosine

8-(Hydroxymethyl)guanosin

8-Hydroxymethyl guanosine

Use of 8-Hydroxymethyl guanosine

Names

8-Hydroxymethyl guanosine Biological Activity

Chemical & Physical Properties

Synonyms