835621-11-9

835621-11-9 structure

Name: Regorafenib N-Oxide(M2)
Chemical Name: bay 75-7495
CAS Number: 835621-11-9
Molecular Formula: C₂₁H₁₅ClF₄N₄O₄
Molecular Weight: 498.81500
Catalog: Research Areas Cancer
Create Date: 2017-07-30 09:17:07
Modify Date: 2024-01-09 19:29:45
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

Name	bay 75-7495
Synonyms	Regorafenib N-oxide (M2 Metabolite) Regorafenib N-Oxide(M2)

Description	Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.