Regorafenib N-Oxide(M2)

Modify Date: 2024-01-09 19:29:45

Regorafenib N-Oxide(M2) Structure
Regorafenib N-Oxide(M2) structure
 Common Name Regorafenib N-Oxide(M2)
CAS Number 835621-11-9 Molecular Weight 498.81500
Density N/A Boiling Point N/A
Molecular Formula C21H15ClF4N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Regorafenib N-Oxide(M2)


Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

 Names

Name bay 75-7495
Synonym More Synonyms

 Regorafenib N-Oxide(M2) Biological Activity

Description Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
Related Catalog
References

[1]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.

 Chemical & Physical Properties

Molecular Formula C21H15ClF4N4O4
Molecular Weight 498.81500
Exact Mass 498.07200
PSA 104.92000
LogP 6.25920

 Synonyms

Regorafenib N-oxide (M2 Metabolite)
Regorafenib N-Oxide(M2)
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